天然多酚作为潜在代谢调节剂通过甲状腺激素受体α激活减轻非酒精性脂肪肝脂肪毒性的硅片研究

IF 3 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current Issues in Molecular Biology Pub Date : 2025-09-19 DOI:10.3390/cimb47090777

Evangelia K Konstantinou, Athanasios A Panagiotopoulos, Maria Dimitriou

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引用次数: 0

摘要

非酒精性脂肪性肝病（NAFLD）是一种由肝脏中甘油三酯沉积所描述的代谢性疾病，主要由胰岛素抵抗和肥胖引起。甲状腺激素受体α (THRA)参与促进脂肪分解的代谢途径，可以防止肝脏脂肪的积累。作为NAFLD的一种可能的治疗方法，这项硅研究检查了水果和蔬菜中存在的THRA与多酚和类黄酮之间的结合相互作用。包括咖啡酸、姜黄素和绿原酸在内的天然物质与THRA的结合亲和力与激素T3相当，促进THRA- trap220复合物，促进脂肪酸氧化，同时减少肝脏中的脂质积累。

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In Silico Study of Natural Polyphenols as Potential Metabolic Modulators in Mitigating Lipotoxicity in Non-Alcoholic Fatty Liver Disease via Thyroid Hormone Receptor Alpha Activation.

Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder described by the deposition of triglycerides in the liver, which primarily occurs due to insulin resistance and obesity. Thyroid hormone receptor alpha (THRA) is involved in metabolic pathways that promote lipolysis, which can prevent the accumulation of liver fat. As a possible treatment for NAFLD, this in silico study examines the binding interactions between THRA and polyphenols and flavonoids present in fruits and vegetables. Including caffeic acid, curcumin, and chlorogenic acid, the binding affinities of the natural substances to THRA were found comparable to the hormone T3, boosting the THRA-TRAP220 complex, promoting fatty acid oxidation, while decreasing lipid accumulation in the liver.

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来源期刊

Current Issues in Molecular Biology 生物-生化研究方法

CiteScore

2.90

自引率

3.20%

发文量

380

审稿时长

>12 weeks

期刊介绍： Current Issues in Molecular Biology (CIMB) is a peer-reviewed journal publishing review articles and minireviews in all areas of molecular biology and microbiology. Submitted articles are subject to an Article Processing Charge (APC) and are open access immediately upon publication. All manuscripts undergo a peer-review process.