gaba能突触的动态和稳态神经元-星形细胞相互作用。

IF 3.8 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Darren Clarke, Jean-Claude Lacaille, Richard Robitaille
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引用次数: 0

摘要

星形胶质细胞通过包括突触调节在内的一系列调节机制支持神经元功能。对星形胶质细胞在兴奋性突触中的传递作用比抑制性突触的作用有更全面的了解。然而,抑制性神经元的突触活动对神经元的活动、回路、大脑状态和功能有着广泛的影响,gaba能抑制性神经元固有的多样性巩固了这一点。本文综述了星形胶质细胞在gaba能抑制性神经元突触中在结构、离子、分子、电路和行为水平上的目的功能,并将多样性纳入目前对抑制性三方突触的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dynamic and Homeostatic Neuron–Astrocyte Interactions at GABAergic Synapses

Astrocytes support neuron function through a range of regulatory mechanisms, including synaptic modulation. There is a more comprehensive understanding of astrocyte contribution to transmission at excitatory synapses than inhibitory synapses. However, the synaptic activity of inhibitory neurons has extensive consequences on neuron activity, circuitry, brain states and function, which is consolidated by the inherent diversity of GABAergic inhibitory neurons. This review provides an overview of the purposeful function of astrocytes at the synapses of GABAergic inhibitory neurons at structural, ionic, molecular, circuit, and behavioral levels and incorporates diversity into the current understanding of inhibitory tripartite synapses.

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来源期刊
Neurochemical Research
Neurochemical Research 医学-神经科学
CiteScore
7.70
自引率
2.30%
发文量
320
审稿时长
6 months
期刊介绍: Neurochemical Research is devoted to the rapid publication of studies that use neurochemical methodology in research on nervous system structure and function. The journal publishes original reports of experimental and clinical research results, perceptive reviews of significant problem areas in the neurosciences, brief comments of a methodological or interpretive nature, and research summaries conducted by leading scientists whose works are not readily available in English.
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