帕金森病骨质疏松症的治疗:范围综述

IF 3.6
Bone Pub Date : 2025-09-25 DOI:10.1016/j.bone.2025.117646
Lyan Abdul Wadood, Victoria McHugh, Kristin K Clemens, Mary E Jenkins, Jeffrey D Holmes, Jamie L Fleet
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引用次数: 0

摘要

背景:帕金森病(PD)是一种主要影响基底神经节多巴胺能神经元的进行性神经退行性疾病。它会导致一系列运动症状,如震颤、运动迟缓、僵硬和步态不稳定。帕金森病的一个重要但经常被忽视的后遗症是骨质疏松症,它导致骨折的发生率更高。帕金森病本身以及用于治疗帕金森病的药物都加剧了这种风险。尽管脆性骨折的风险增加,PD中的骨质疏松症经常被低估和管理不足。目的:本综述旨在探讨目前关于帕金森病患者骨质疏松症管理策略的文献。方法:检索自建库至2025年8月10日的MEDLINE、Scopus和EMBASE数据库。结果:经过两名独立审稿人进行的两阶段评审过程,确定了18篇相关文章。其中,17篇是综述性文章,1篇是干预性研究。文献中最常见的是将生活方式改变、药物治疗和手术干预作为帕金森病骨质疏松症的管理策略。然而,大多数建议都是基于在普通人群中进行的研究,这引起了人们对PD患者有效性的担忧,他们可能有独特的临床需求。结论:我们注意到PD患者骨质疏松症管理方面的研究存在显著差距。研究工作应优先考虑制定针对性的策略来管理PD患者的骨质疏松症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Management of osteoporosis in Parkinson's disease: A scoping review.

Background: Parkinson's Disease (PD) is a progressive neurodegenerative disorder that primarily affects the dopaminergic neurons in the basal ganglia. It leads to a range of motor symptoms such as tremors, bradykinesia, rigidity, and gait instability. A significant, but often overlooked, sequela of PD is osteoporosis, which contributes to a higher incidence of fractures. This risk is exacerbated by both PD itself as well as the medications used to manage PD. Despite the heightened risk of fragility fractures, osteoporosis in PD is frequently under-recognized and inadequately managed.

Objective: This review aimed to explore the current literature on osteoporosis management strategies specifically for individuals with PD.

Methods: MEDLINE, Scopus, and EMBASE were searched from database inception to August 10, 2025.

Results: Following a two-stage review process conducted by two independent reviewers, 18 relevant articles were identified. Of these, 17 were review articles and one was an interventional study. The literature most commonly identified lifestyle modifications, pharmacological treatments, and surgical interventions as management strategies for osteoporosis in PD. However, most of the recommendations were based on research conducted in the general population, raising concerns about their effectiveness for individuals with PD, who may have unique clinical needs.

Conclusions: We note a significant gap in research focused on osteoporosis management in PD patients. Research efforts should prioritize developing tailored strategies to manage osteoporosis in individuals with PD.

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