8-氧-2 ' -脱氧鸟苷：氧化应激控制

IF 1.7 4区化学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Russian Journal of Bioorganic Chemistry Pub Date : 2025-09-28 DOI:10.1134/S1068162025602472

N. V. Marmiy, D. S. Esipov

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引用次数: 0

摘要

8-氧-2 ' -脱氧鸟苷是众所周知的氧化应激标志物。过去十年的研究表明，这种化合物可能不是氧化DNA损伤的副产物，而是驱动细胞对压力反应的重要生物调节剂。本文收集并分析了8-oxo-2 ' -脱氧鸟苷参与突变、DNA修复、基因表达调控、炎症反应、适应性应激反应、细胞凋亡和细胞转化等过程的相关数据。特别关注8-氧-2 ' -脱氧鸟苷作为治疗炎症、自身免疫、退行性和肿瘤性疾病以及创伤性和毒性损伤的治疗剂的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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8-Oxo-2′-Deoxyguanosine: Oxidative Stress Control

8-Oxo-2′-deoxyguanosine is a well-known marker of oxidative stress. Research over the past decade suggests that this compound is probably not a byproduct of oxidative DNA damage, but an important bioregulator driving the cellular response to stress. This review collected and analyzed data on the participation of 8-oxo-2′-deoxyguanosine in the processes of mutagenesis, DNA repair, and regulation of gene expression, inflammatory responses, adaptive stress response, apoptosis, and cellular transformation. Particular attention is paid to the potential of 8-oxo-2′-deoxyguanosine as a therapeutic agent for the treatment of inflammatory, autoimmune, degenerative, and oncological diseases, as well as of traumatic and toxic injuries.

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来源期刊

Russian Journal of Bioorganic Chemistry 生物-生化与分子生物学

CiteScore

1.80

自引率

10.00%

发文量

118

审稿时长

3 months

期刊介绍： Russian Journal of Bioorganic Chemistry publishes reviews and original experimental and theoretical studies on the structure, function, structure–activity relationships, and synthesis of biopolymers, such as proteins, nucleic acids, polysaccharides, mixed biopolymers, and their complexes, and low-molecular-weight biologically active compounds (peptides, sugars, lipids, antibiotics, etc.). The journal also covers selected aspects of neuro- and immunochemistry, biotechnology, and ecology.