{"title":"超声介导的微泡破坏增强放射药物进入免疫抵抗肺癌肿瘤微环境的途径。","authors":"Xue Yu, Shuai Zheng, Long Zhao, Kai Zhang","doi":"10.1177/10849785251371491","DOIUrl":null,"url":null,"abstract":"<p><p><b><i>Background:</i></b> Immune-resistant lung carcinoma poses a major hurdle for effective cancer treatment, largely due to its dense tumor microenvironment (TME) and the challenges of drug penetration. To boost the effectiveness of radiopharmaceuticals in this intricate TME, focused ultrasound-mediated microbubble cavitation (FUS-MMC) needs to enhance their accessibility. Current delivery methods often fall short, suffering from limited vascular permeability and insufficient tumor uptake. This results in less effective treatments and increased off-target toxicity. <b><i>Methods:</i></b> To address this issue, this article proposes a targeted delivery framework that utilizes FUS-MMC. This innovative technique involves administering microbubbles systemically and directing ultrasound precisely to disrupt the tumor's blood vessels and extracellular matrix temporarily. By using the FUS-MMC approach, the permeability of the TME is improved, allowing radiopharmaceuticals like 177Lu-DOTATATE to penetrate deeper into the tumor tissues. This enhanced access leads to a more even distribution and greater accumulation of therapeutic agents right at the tumor site. <b><i>Results and Conclusion:</i></b> FUS-MMC significantly boosts the efficiency of radiopharmaceutical delivery, reduces systemic exposure, and improves tumor response rates in models of immune-resistant lung carcinoma. This noninvasive and repeatable strategy represents a promising step forward in precision oncology and targeted cancer therapy.</p>","PeriodicalId":55277,"journal":{"name":"Cancer Biotherapy and Radiopharmaceuticals","volume":" ","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ultrasound-Mediated Microbubble Disruption to Enhance Radiopharmaceutical Access to the Tumor Microenvironment in Immune-Resistant Lung Carcinoma.\",\"authors\":\"Xue Yu, Shuai Zheng, Long Zhao, Kai Zhang\",\"doi\":\"10.1177/10849785251371491\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b><i>Background:</i></b> Immune-resistant lung carcinoma poses a major hurdle for effective cancer treatment, largely due to its dense tumor microenvironment (TME) and the challenges of drug penetration. To boost the effectiveness of radiopharmaceuticals in this intricate TME, focused ultrasound-mediated microbubble cavitation (FUS-MMC) needs to enhance their accessibility. Current delivery methods often fall short, suffering from limited vascular permeability and insufficient tumor uptake. This results in less effective treatments and increased off-target toxicity. <b><i>Methods:</i></b> To address this issue, this article proposes a targeted delivery framework that utilizes FUS-MMC. This innovative technique involves administering microbubbles systemically and directing ultrasound precisely to disrupt the tumor's blood vessels and extracellular matrix temporarily. By using the FUS-MMC approach, the permeability of the TME is improved, allowing radiopharmaceuticals like 177Lu-DOTATATE to penetrate deeper into the tumor tissues. This enhanced access leads to a more even distribution and greater accumulation of therapeutic agents right at the tumor site. <b><i>Results and Conclusion:</i></b> FUS-MMC significantly boosts the efficiency of radiopharmaceutical delivery, reduces systemic exposure, and improves tumor response rates in models of immune-resistant lung carcinoma. This noninvasive and repeatable strategy represents a promising step forward in precision oncology and targeted cancer therapy.</p>\",\"PeriodicalId\":55277,\"journal\":{\"name\":\"Cancer Biotherapy and Radiopharmaceuticals\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-09-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cancer Biotherapy and Radiopharmaceuticals\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/10849785251371491\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Biotherapy and Radiopharmaceuticals","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/10849785251371491","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Ultrasound-Mediated Microbubble Disruption to Enhance Radiopharmaceutical Access to the Tumor Microenvironment in Immune-Resistant Lung Carcinoma.
Background: Immune-resistant lung carcinoma poses a major hurdle for effective cancer treatment, largely due to its dense tumor microenvironment (TME) and the challenges of drug penetration. To boost the effectiveness of radiopharmaceuticals in this intricate TME, focused ultrasound-mediated microbubble cavitation (FUS-MMC) needs to enhance their accessibility. Current delivery methods often fall short, suffering from limited vascular permeability and insufficient tumor uptake. This results in less effective treatments and increased off-target toxicity. Methods: To address this issue, this article proposes a targeted delivery framework that utilizes FUS-MMC. This innovative technique involves administering microbubbles systemically and directing ultrasound precisely to disrupt the tumor's blood vessels and extracellular matrix temporarily. By using the FUS-MMC approach, the permeability of the TME is improved, allowing radiopharmaceuticals like 177Lu-DOTATATE to penetrate deeper into the tumor tissues. This enhanced access leads to a more even distribution and greater accumulation of therapeutic agents right at the tumor site. Results and Conclusion: FUS-MMC significantly boosts the efficiency of radiopharmaceutical delivery, reduces systemic exposure, and improves tumor response rates in models of immune-resistant lung carcinoma. This noninvasive and repeatable strategy represents a promising step forward in precision oncology and targeted cancer therapy.
期刊介绍:
Cancer Biotherapy and Radiopharmaceuticals is the established peer-reviewed journal, with over 25 years of cutting-edge content on innovative therapeutic investigations to ultimately improve cancer management. It is the only journal with the specific focus of cancer biotherapy and is inclusive of monoclonal antibodies, cytokine therapy, cancer gene therapy, cell-based therapies, and other forms of immunotherapies.
The Journal includes extensive reporting on advancements in radioimmunotherapy, and the use of radiopharmaceuticals and radiolabeled peptides for the development of new cancer treatments.