近红外光免疫治疗靶膜蛋白研究综述

IF 4.8 3区医学 Q2 CHEMISTRY, MEDICINAL

Pharmaceuticals Pub Date : 2025-09-21 DOI:10.3390/ph18091419

Motofumi Suzuki, Hirofumi Hanaoka

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引用次数: 0

摘要

近红外光免疫疗法（NIR- pit）是最近发展起来的一种利用抗体-光吸收剂（irdye - 700dx [IR700]）偶联物和近红外光的癌症治疗方法。当这种结合物与癌细胞上的抗原结合并暴露在近红外光下时，可诱导与致命膜损伤相关的坏死细胞死亡。因此，各种膜蛋白是NIR-PIT潜在的治疗靶点，许多研究已经描述了各种靶分子和特异性抗体。选择合适的靶膜蛋白和单克隆抗体是未来NIR-PIT药物开发的关键。本文对NIR-PIT的膜靶点和抗体进行了综述，重点介绍了每个分子的特征。

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An Overview of Target Membrane Proteins for Near-Infrared Photoimmunotherapy.

Near-infrared photoimmunotherapy (NIR-PIT) is a recently developed cancer treatment that utilizes antibody-photoabsorber (IRDye700DX [IR700]) conjugates and NIR light. Necrotic cell death associated with lethal membrane damage is induced when this conjugate binds to an antigen on cancer cells, and it is exposed to NIR light. Therefore, various membrane proteins are potential therapeutic targets for NIR-PIT, and many studies have described various target molecules and specific antibodies. To develop future drugs for NIR-PIT, the selection of appropriate target membrane proteins and monoclonal antibodies will be important. In this review, we summarize the membrane targets and antibodies for NIR-PIT used in previous studies, focusing on the characteristics of each molecule.

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来源期刊

Pharmaceuticals Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

6.10

自引率

4.30%

发文量

1332

审稿时长

6 weeks

期刊介绍： Pharmaceuticals (ISSN 1424-8247) is an international scientific journal of medicinal chemistry and related drug sciences.Our aim is to publish updated reviews as well as research articles with comprehensive theoretical and experimental details. Short communications are also accepted; therefore, there is no restriction on the maximum length of the papers.