Zoe D Draelos, Matthew M Draelos, Kizito Kyeremateng, Nicholas Squittieri
{"title":"在体外与局部痤疮药物联合时，Clascoterone的稳定性。","authors":"Zoe D Draelos, Matthew M Draelos, Kizito Kyeremateng, Nicholas Squittieri","doi":"10.1007/s13555-025-01553-5","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Multimodal topical therapy is recommended by the American Academy of Dermatology for the treatment of acne vulgaris. However, no data are available regarding stability of clascoterone cream 1% when combined with other topical acne medications. The purpose of this study was to evaluate the stability of clascoterone in the presence of tretinoin, adapalene, dapsone, azelaic acid, benzoyl peroxide (BP)/clindamycin, BP/adapalene, and encapsulated BP.</p><p><strong>Methods: </strong>Clascoterone cream (0.5 mL) was layered over 0.5 mL of each of the other products on an individual microscope slide and incubated for 8 h at 37 °C. Material from the slides was extracted in methanol and tetrahydrofuran for high-pressure liquid chromatography mass spectrometry (1 mL/min flow rate; 30 °C). Combinations of clascoterone with tretinoin and adapalene were reinjected 12 h after the initial injections to confirm consistent clascoterone detection. Percent recovery of clascoterone for each combination was calculated from a standard curve serially diluted in methanol.</p><p><strong>Results: </strong>The mean percentage of clascoterone recovered after incubation with other drugs ranged from 98% to 119%, with 86% recovered following injection of clascoterone alone. Reinjected clascoterone-tretinoin and clascoterone-adapalene samples yielded clascoterone recovery percentages of 97% and 93%, respectively, both within 8% of those recovered from the initial injections.</p><p><strong>Conclusions: </strong>Clascoterone demonstrated consistent and reproducible stability in the presence of other topical acne medications.</p>","PeriodicalId":11186,"journal":{"name":"Dermatology and Therapy","volume":" ","pages":""},"PeriodicalIF":4.2000,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clascoterone Stability When Combined with Topical Acne Medications In Vitro.\",\"authors\":\"Zoe D Draelos, Matthew M Draelos, Kizito Kyeremateng, Nicholas Squittieri\",\"doi\":\"10.1007/s13555-025-01553-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Multimodal topical therapy is recommended by the American Academy of Dermatology for the treatment of acne vulgaris. However, no data are available regarding stability of clascoterone cream 1% when combined with other topical acne medications. The purpose of this study was to evaluate the stability of clascoterone in the presence of tretinoin, adapalene, dapsone, azelaic acid, benzoyl peroxide (BP)/clindamycin, BP/adapalene, and encapsulated BP.</p><p><strong>Methods: </strong>Clascoterone cream (0.5 mL) was layered over 0.5 mL of each of the other products on an individual microscope slide and incubated for 8 h at 37 °C. Material from the slides was extracted in methanol and tetrahydrofuran for high-pressure liquid chromatography mass spectrometry (1 mL/min flow rate; 30 °C). Combinations of clascoterone with tretinoin and adapalene were reinjected 12 h after the initial injections to confirm consistent clascoterone detection. Percent recovery of clascoterone for each combination was calculated from a standard curve serially diluted in methanol.</p><p><strong>Results: </strong>The mean percentage of clascoterone recovered after incubation with other drugs ranged from 98% to 119%, with 86% recovered following injection of clascoterone alone. Reinjected clascoterone-tretinoin and clascoterone-adapalene samples yielded clascoterone recovery percentages of 97% and 93%, respectively, both within 8% of those recovered from the initial injections.</p><p><strong>Conclusions: </strong>Clascoterone demonstrated consistent and reproducible stability in the presence of other topical acne medications.</p>\",\"PeriodicalId\":11186,\"journal\":{\"name\":\"Dermatology and Therapy\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2025-09-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dermatology and Therapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s13555-025-01553-5\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dermatology and Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s13555-025-01553-5","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Clascoterone Stability When Combined with Topical Acne Medications In Vitro.
Introduction: Multimodal topical therapy is recommended by the American Academy of Dermatology for the treatment of acne vulgaris. However, no data are available regarding stability of clascoterone cream 1% when combined with other topical acne medications. The purpose of this study was to evaluate the stability of clascoterone in the presence of tretinoin, adapalene, dapsone, azelaic acid, benzoyl peroxide (BP)/clindamycin, BP/adapalene, and encapsulated BP.
Methods: Clascoterone cream (0.5 mL) was layered over 0.5 mL of each of the other products on an individual microscope slide and incubated for 8 h at 37 °C. Material from the slides was extracted in methanol and tetrahydrofuran for high-pressure liquid chromatography mass spectrometry (1 mL/min flow rate; 30 °C). Combinations of clascoterone with tretinoin and adapalene were reinjected 12 h after the initial injections to confirm consistent clascoterone detection. Percent recovery of clascoterone for each combination was calculated from a standard curve serially diluted in methanol.
Results: The mean percentage of clascoterone recovered after incubation with other drugs ranged from 98% to 119%, with 86% recovered following injection of clascoterone alone. Reinjected clascoterone-tretinoin and clascoterone-adapalene samples yielded clascoterone recovery percentages of 97% and 93%, respectively, both within 8% of those recovered from the initial injections.
Conclusions: Clascoterone demonstrated consistent and reproducible stability in the presence of other topical acne medications.
期刊介绍：
Dermatology and Therapy is an international, open access, peer-reviewed, rapid publication journal (peer review in 2 weeks, published 3–4 weeks from acceptance). The journal is dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of dermatological therapies. Studies relating to diagnosis, pharmacoeconomics, public health and epidemiology, quality of life, and patient care, management, and education are also encouraged.
Areas of focus include, but are not limited to all clinical aspects of dermatology, such as skin pharmacology; skin development and aging; prevention, diagnosis, and management of skin disorders and melanomas; research into dermal structures and pathology; and all areas of aesthetic dermatology, including skin maintenance, dermatological surgery, and lasers.
The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/case series, trial protocols, and short communications. Dermatology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an International and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. The journal appeals to a global audience and receives submissions from all over the world.
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