{"title":"放射性碘化二氧化硅包覆磁性纳米颗粒作为骨成像SPECT/MR双模探针的合成","authors":"Noha A. Bayoumi","doi":"10.1007/s12247-025-10011-w","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>A reliable imaging probe is essential for the accurate diagnosis of diseases and to support effective therapeutic decision-making. Different nanoparticles based multimodal probes have been studied for bone imaging. This work focuses on synthesizing of radiolabeled iron oxide magnetic nanoparticles as a promising dual modality bioprobe (SPECT/MR) for bone imaging.</p><h3>Methods</h3><p>In this work, silica coated magnetic nanoparticles (SiO<sub>2</sub>@MNPs) were synthesized. Radioiodination of SiO<sub>2</sub>@MNPs with iodine − 131 was performed via the Finkelstein reaction to produce a prospective radioiodinated MNPs for bone targeting.</p><h3>Results</h3><p>The radioiodinated NPs were obtained in high radiochemical purity (about 98.5 ± 0.5%) by magnet separation. The aqueous dispersion of the radioiodinated silica coated MNPs (<sup>131</sup>I-SiO<sub>2</sub>@MNPs) exhibited adequate in-vitro stability and biocompatibility. Biodistribution study results after intravenous injection of (<sup>131</sup>I-SiO<sub>2</sub>@MNPs) in normal mice revealed the high bone targeting efficiency of the radiolabeled NPs (C<sub>max</sub>= 6± 0.5% ID/g at t<sub>max</sub>= 2 h post injection). Magnetization properties measurements proved the preservation of the magnetic properties of SiO<sub>2</sub>@MNPs after the iodination process retaining its effectiveness as MRI contrast agent.</p><h3>Conclusion</h3><p>Based on to the results of this study, <sup>131</sup>I-SiO<sub>2</sub>@MNPs could be considered as a promising candidate for SPECT/MR dual bone imaging.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"20 4","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12247-025-10011-w.pdf","citationCount":"0","resultStr":"{\"title\":\"Synthesis of Radioiodinated Silica-Coated Magnetic Nanoparticles as SPECT/MR Dual-Modality Probe for Bone Imaging\",\"authors\":\"Noha A. Bayoumi\",\"doi\":\"10.1007/s12247-025-10011-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>A reliable imaging probe is essential for the accurate diagnosis of diseases and to support effective therapeutic decision-making. Different nanoparticles based multimodal probes have been studied for bone imaging. This work focuses on synthesizing of radiolabeled iron oxide magnetic nanoparticles as a promising dual modality bioprobe (SPECT/MR) for bone imaging.</p><h3>Methods</h3><p>In this work, silica coated magnetic nanoparticles (SiO<sub>2</sub>@MNPs) were synthesized. Radioiodination of SiO<sub>2</sub>@MNPs with iodine − 131 was performed via the Finkelstein reaction to produce a prospective radioiodinated MNPs for bone targeting.</p><h3>Results</h3><p>The radioiodinated NPs were obtained in high radiochemical purity (about 98.5 ± 0.5%) by magnet separation. The aqueous dispersion of the radioiodinated silica coated MNPs (<sup>131</sup>I-SiO<sub>2</sub>@MNPs) exhibited adequate in-vitro stability and biocompatibility. Biodistribution study results after intravenous injection of (<sup>131</sup>I-SiO<sub>2</sub>@MNPs) in normal mice revealed the high bone targeting efficiency of the radiolabeled NPs (C<sub>max</sub>= 6± 0.5% ID/g at t<sub>max</sub>= 2 h post injection). Magnetization properties measurements proved the preservation of the magnetic properties of SiO<sub>2</sub>@MNPs after the iodination process retaining its effectiveness as MRI contrast agent.</p><h3>Conclusion</h3><p>Based on to the results of this study, <sup>131</sup>I-SiO<sub>2</sub>@MNPs could be considered as a promising candidate for SPECT/MR dual bone imaging.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":656,\"journal\":{\"name\":\"Journal of Pharmaceutical Innovation\",\"volume\":\"20 4\",\"pages\":\"\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-06-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s12247-025-10011-w.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pharmaceutical Innovation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s12247-025-10011-w\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmaceutical Innovation","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s12247-025-10011-w","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Synthesis of Radioiodinated Silica-Coated Magnetic Nanoparticles as SPECT/MR Dual-Modality Probe for Bone Imaging
Purpose
A reliable imaging probe is essential for the accurate diagnosis of diseases and to support effective therapeutic decision-making. Different nanoparticles based multimodal probes have been studied for bone imaging. This work focuses on synthesizing of radiolabeled iron oxide magnetic nanoparticles as a promising dual modality bioprobe (SPECT/MR) for bone imaging.
Methods
In this work, silica coated magnetic nanoparticles (SiO2@MNPs) were synthesized. Radioiodination of SiO2@MNPs with iodine − 131 was performed via the Finkelstein reaction to produce a prospective radioiodinated MNPs for bone targeting.
Results
The radioiodinated NPs were obtained in high radiochemical purity (about 98.5 ± 0.5%) by magnet separation. The aqueous dispersion of the radioiodinated silica coated MNPs (131I-SiO2@MNPs) exhibited adequate in-vitro stability and biocompatibility. Biodistribution study results after intravenous injection of (131I-SiO2@MNPs) in normal mice revealed the high bone targeting efficiency of the radiolabeled NPs (Cmax= 6± 0.5% ID/g at tmax= 2 h post injection). Magnetization properties measurements proved the preservation of the magnetic properties of SiO2@MNPs after the iodination process retaining its effectiveness as MRI contrast agent.
Conclusion
Based on to the results of this study, 131I-SiO2@MNPs could be considered as a promising candidate for SPECT/MR dual bone imaging.
期刊介绍：
The Journal of Pharmaceutical Innovation (JPI), is an international, multidisciplinary peer-reviewed scientific journal dedicated to publishing high quality papers emphasizing innovative research and applied technologies within the pharmaceutical and biotechnology industries. JPI''s goal is to be the premier communication vehicle for the critical body of knowledge that is needed for scientific evolution and technical innovation, from R&D to market. Topics will fall under the following categories:
Materials science,
Product design,
Process design, optimization, automation and control,
Facilities; Information management,
Regulatory policy and strategy,
Supply chain developments ,
Education and professional development,
Journal of Pharmaceutical Innovation publishes four issues a year.
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