Diego I. Figueroa-Figueroa, Francisco Hernández-Luis
{"title":"二茂铁光敏剂的研究进展：照亮癌症药物化学的新途径","authors":"Diego I. Figueroa-Figueroa, Francisco Hernández-Luis","doi":"10.1007/s00044-025-03432-2","DOIUrl":null,"url":null,"abstract":"<div><p>Photodynamic therapy (PDT) is a promising treatment for diseases like cancer and microbial infections, relying on light-activated photosensitizers to generate cytotoxic reactive oxygen species. While PDT has shown clinical success, developing novel photosensitizers with improved properties remains challenging. Ferrocene, with its unique stability, redox activity, and tunability, offers an attractive scaffold for this purpose. This review delves into the recent advancements in ferrocene-based photosensitizers, exploring their design strategies, mechanisms of action, and diverse applications in medicinal chemistry. We critically discuss their potential, comparing structure-activity relationships across various ferrocene derivatives and evaluating their performance in in vitro cell line assays. Additionally, we address current challenges and future directions, highlighting their potential to significantly advance PDT and offer new therapeutic avenues.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":699,"journal":{"name":"Medicinal Chemistry Research","volume":"34 7","pages":"1480 - 1495"},"PeriodicalIF":3.1000,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00044-025-03432-2.pdf","citationCount":"0","resultStr":"{\"title\":\"Advances in ferrocene photosensitizers: illuminating new avenues in the medicinal chemistry of cancer\",\"authors\":\"Diego I. Figueroa-Figueroa, Francisco Hernández-Luis\",\"doi\":\"10.1007/s00044-025-03432-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Photodynamic therapy (PDT) is a promising treatment for diseases like cancer and microbial infections, relying on light-activated photosensitizers to generate cytotoxic reactive oxygen species. While PDT has shown clinical success, developing novel photosensitizers with improved properties remains challenging. Ferrocene, with its unique stability, redox activity, and tunability, offers an attractive scaffold for this purpose. This review delves into the recent advancements in ferrocene-based photosensitizers, exploring their design strategies, mechanisms of action, and diverse applications in medicinal chemistry. We critically discuss their potential, comparing structure-activity relationships across various ferrocene derivatives and evaluating their performance in in vitro cell line assays. Additionally, we address current challenges and future directions, highlighting their potential to significantly advance PDT and offer new therapeutic avenues.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":699,\"journal\":{\"name\":\"Medicinal Chemistry Research\",\"volume\":\"34 7\",\"pages\":\"1480 - 1495\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-06-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s00044-025-03432-2.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medicinal Chemistry Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s00044-025-03432-2\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicinal Chemistry Research","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s00044-025-03432-2","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Advances in ferrocene photosensitizers: illuminating new avenues in the medicinal chemistry of cancer
Photodynamic therapy (PDT) is a promising treatment for diseases like cancer and microbial infections, relying on light-activated photosensitizers to generate cytotoxic reactive oxygen species. While PDT has shown clinical success, developing novel photosensitizers with improved properties remains challenging. Ferrocene, with its unique stability, redox activity, and tunability, offers an attractive scaffold for this purpose. This review delves into the recent advancements in ferrocene-based photosensitizers, exploring their design strategies, mechanisms of action, and diverse applications in medicinal chemistry. We critically discuss their potential, comparing structure-activity relationships across various ferrocene derivatives and evaluating their performance in in vitro cell line assays. Additionally, we address current challenges and future directions, highlighting their potential to significantly advance PDT and offer new therapeutic avenues.
期刊介绍：
Medicinal Chemistry Research (MCRE) publishes papers on a wide range of topics, favoring research with significant, new, and up-to-date information. Although the journal has a demanding peer review process, MCRE still boasts rapid publication, due in part, to the length of the submissions. The journal publishes significant research on various topics, many of which emphasize the structure-activity relationships of molecular biology.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
