丙炔醇与苯胺在多磷酸介质中反应合成2,4-二取代喹啉

IF 0.9 4区化学 Q4 CHEMISTRY, ORGANIC

Russian Journal of Organic Chemistry Pub Date : 2025-07-13 DOI:10.1134/S1070428025602687

A. V. Aksenov, N. A. Aksenov, A. S. Akulova, D. C. Makieva, I. V. Aksenova, N. A. Arutiunov, D. A. Aksenov

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引用次数: 0

摘要

在多磷酸（PPA）存在下，利用丙炔醇与苯胺的相互作用合成喹啉。已经发现丙炔醇在PPA介质中能够水解成查尔酮。首次证实了PPA在乙酸乙酯溶液中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of 2,4-Disubstituted Quinolines by the Reaction of Propargylic Alcohols with Anilines in a Polyphosphoric Acid Medium

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Synthesis of 2,4-Disubstituted Quinolines by the Reaction of Propargylic Alcohols with Anilines in a Polyphosphoric Acid Medium

A novel method for quinoline synthesis based on the interaction of propargylic alcohols with anilines in the presence of polyphosphoric acid (PPA) has been developed. It has been discovered that propargylic alcohols in a PPA medium are capable of hydrolyzing into chalcones. The use of PPA in ethyl acetate solution has been demonstrated for the first time.

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来源期刊

Russian Journal of Organic Chemistry 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

139

审稿时长

3-6 weeks

期刊介绍： Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.