芍药苷衍生物及其生物活性研究综述

IF 3.1 4区医学 Q3 CHEMISTRY, MEDICINAL

Medicinal Chemistry Research Pub Date : 2025-06-05 DOI:10.1007/s00044-025-03429-x

Qian Xiao, Hua Han, Peiliang Dong

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引用次数: 0

摘要

芍药苷是芍药根的有效成分之一，具有强大而多样的药理活性。然而，低膜通透性和胃肠道效应严重限制了其吸收和生物利用度。本文收集了190种芍药苷衍生物，包括天然衍生物和人工合成衍生物。综述了活性较强的衍生物的药理作用。此外，还对芍药苷的构效关系进行了适当的总结。本文旨在为芍药苷的进一步研究和临床应用提供有价值的帮助。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Summary of paeoniflorin derivatives and their biological activities

Paeoniflorin is one of the active components of the root of peony, which has powerful and diverse pharmacological activities. However, low membrane permeability and gastrointestinal effects severely limit its absorption and bioavailability. In this paper, 190 paeoniflorin derivatives, including natural derivatives and synthetic derivatives, were collected. The pharmacological effects of the more active derivatives were summarized. In addition, the structure-activity relationship of paeoniflorin was appropriately summarized. This review aims to provide valuable assistance for further research and clinical application of paeoniflorin.

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来源期刊

Medicinal Chemistry Research 医学-医药化学

CiteScore

4.70

自引率

3.80%

发文量

162

审稿时长

5.0 months

期刊介绍： Medicinal Chemistry Research (MCRE) publishes papers on a wide range of topics, favoring research with significant, new, and up-to-date information. Although the journal has a demanding peer review process, MCRE still boasts rapid publication, due in part, to the length of the submissions. The journal publishes significant research on various topics, many of which emphasize the structure-activity relationships of molecular biology.