TOEPyP4和ZnTOEPyP4卟啉与g -四络合物的相互作用

IF 0.4 4区物理与天体物理 Q4 PHYSICS, MULTIDISCIPLINARY

Journal of Contemporary Physics (Armenian Academy of Sciences) Pub Date : 2025-07-04 DOI:10.1134/S1068337225700410

I. V. Vardanyan, M. Kh. Badalyan, Ts. M. Jomardyan, Y. B. Dalyan, S. G. Haroutiunian

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引用次数: 0

摘要

采用圆二色法和紫外/可见分光光度法研究了两种阳离子卟啉中四（4n -氧乙基吡啶基）卟啉（TOEPyP4）及其含锌衍生物（ZnTOEPyP4）对人端粒DNA d[5'- a (GGGTTA)3GGG-3']序列g -四重构象的影响。分析结果表明，这些卟啉的结合位点是单一的，但根据卟啉的不同而不同。假设TOEPyP4在g -四重体的外表面与四重体平面平行结合（外部π-π堆叠），ZnTOEPyP4的结合也发生在外部，但在g -四重体侧面的凹槽中（凹槽结合）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The Interaction of TOEPyP4 and ZnTOEPyP4 Porphyrins with G-Quadruplexes

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The Interaction of TOEPyP4 and ZnTOEPyP4 Porphyrins with G-Quadruplexes

The methods of Circular Dichroism and UV/Vis spectrophotometry were used to study the influence of two cationic porphyrins meso-tetra-(4N-oxyethylpyridyl) porphyrin (TOEPyP4) and its Zn-containing derivative (ZnTOEPyP4) on the G-quadruplex conformation of d[5'-A(GGGTTA)₃GGG-3'] sequence of human telomeric DNA. The analysis of the results indicates a single binding site for these porphyrins, but it differs depending on the porphyrin. It is assumed that TOEPyP4 binds parallel to the quartet plane on the outer surface of the G-quadruplex (external π-π stacking), and the binding of ZnTOEPyP4 also occurs externally, but in the groove of the lateral surface of the G-quadruplex (groove binding).

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来源期刊

Journal of Contemporary Physics (Armenian Academy of Sciences) PHYSICS, MULTIDISCIPLINARY-

CiteScore

1.00

自引率

66.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Journal of Contemporary Physics (Armenian Academy of Sciences) is a journal that covers all fields of modern physics. It publishes significant contributions in such areas of theoretical and applied science as interaction of elementary particles at superhigh energies, elementary particle physics, charged particle interactions with matter, physics of semiconductors and semiconductor devices, physics of condensed matter, radiophysics and radioelectronics, optics and quantum electronics, quantum size effects, nanophysics, sensorics, and superconductivity.