含有姜黄素和维地内酯的电纺纳米纤维创面敷料的研制与评价

IF 2.7 4区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of Pharmaceutical Innovation Pub Date : 2025-07-02 DOI:10.1007/s12247-025-10001-y

Deepika Sharma, Shriyansh Srivastava, Sachin Kumar, Abdul Rahaman, Rupali Sharma, Vipin Kumar Garg, Sumel Ashique, Siva Prasad Panda, Uttam Prasad Panigrahy, Sabina Yasmin, Kumar Venkatesan, Mohammad Yousuf Ansari

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引用次数: 0

摘要

聚乙烯醇（PVA）广泛用于支架制造，其渗透性、柔软性和透明度使其成为理想的伤口愈合应用。本研究旨在通过将姜黄素和维德内酯等生物活性化合物掺入静电纺聚乙烯醇纳米纤维中，利用其抗氧化、抗菌、抗炎和镇痛特性，促进伤口愈合。方法采用先进的静电纺丝技术，以聚乙烯醇、姜黄素和维地内酯为原料，精心制备了新型聚合物纳米纤维支架，展示了其在各种应用领域的潜力。扫描电镜（SEM）、紫外可见光谱（UV-visible spectroscopy）、红外光谱（FTIR spectroscopy）、x射线衍射（XRD）、折叠耐久试验和体外药物释放动力学等方法对支架进行了表征。使用Wistar白化病大鼠模型和切除和切口伤口模型来评估支架促进伤口愈合的能力。结果表征技术证实了姜黄素和维德内酯在PVA纳米纤维中的成功掺入。全层创面大鼠体内实验显示，PVA/Cur/Wed纳米纤维创面愈合时间为第13天，对照组创面愈合时间为第15天。第12天NS为18.33±2.19(96.32%)mm2，对照组为274.16±2.36 (44.65%)mm2，显著优于对照组。结论姜黄素与维地内酯复合制备PVA纳米纤维支架可促进创面愈合，为临床改善创面护理和加速创面恢复提供了一种潜在的治疗策略。图形抽象

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Development and Assessment of Electrospun Nanofibrous Wound Dressing Containing Curcumin and Wedelolactone

Purpose

Polyvinyl alcohol (PVA), widely used in scaffold fabrication, is valued for its permeability, softness, and transparency, making it ideal for wound-healing applications. This study aims to enhance wound healing by incorporating bioactive compounds, curcumin and wedelolactone, into electrospun PVA nanofibers, leveraging their antioxidant, antibacterial, anti-inflammatory, and analgesic properties.

Method

Innovative polymeric nanofibrous scaffolds crafted from PVA, curcumin, and wedelolactone have been expertly developed through advanced electrospinning techniques, showcasing their potential in various applications. Scanning Electron Microscopy (SEM), UV–visible spectroscopy, FTIR spectroscopy, X-ray diffraction (XRD), folding endurance tests, and in vitro drug release kinetics were among the methods used to characterize the scaffolds. The scaffolds' ability to promote wound healing was evaluated in vivo using a Wistar albino rat model with excision and incision wound models.

Results

Characterization techniques confirmed the successful incorporation of curcumin and wedelolactone into the PVA nanofibers. Rats with full-thickness wounds showed in vivo that PVA/Cur/Wed nanofibers healed the wounds on the 13th day compared to the 15th day for the control group, which received commercial povidone ointment. On the 12th day, NS had 18.33 ± 2.19(96.32%) mm2, whereas the control group had 274.16 ± 2.36 (44.65%)mm2, significantly more effective than the control group.

Conclusion

The results demonstrate that combining curcumin and wedelolactone in PVA nanofibrous scaffolds enhances wound healing, suggesting a potential therapeutic strategy for improving wound care and accelerating recovery in clinical settings.

Graphical Abstract

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来源期刊

Journal of Pharmaceutical Innovation PHARMACOLOGY & PHARMACY-

CiteScore

3.70

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Pharmaceutical Innovation (JPI), is an international, multidisciplinary peer-reviewed scientific journal dedicated to publishing high quality papers emphasizing innovative research and applied technologies within the pharmaceutical and biotechnology industries. JPI''s goal is to be the premier communication vehicle for the critical body of knowledge that is needed for scientific evolution and technical innovation, from R&D to market. Topics will fall under the following categories: Materials science, Product design, Process design, optimization, automation and control, Facilities; Information management, Regulatory policy and strategy, Supply chain developments , Education and professional development, Journal of Pharmaceutical Innovation publishes four issues a year.