滤泡辅助性T细胞与纤维化疾病

IF 2.9 4区医学 Q2 CELL BIOLOGY

Cellular immunology Pub Date : 2025-09-13 DOI:10.1016/j.cellimm.2025.105024

Yixuan Ma , Yue Zhou , Miao Yu

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引用次数: 0

摘要

T滤泡辅助细胞（Tfh）是CD4+ T淋巴细胞的一个功能特异的亚群，它协调生发中心（GC）反应，关键地调节B细胞的目的地和长期体液免疫的发展。新出现的证据表明，Tfh细胞是跨多器官系统的多种纤维化疾病发病机制的关键介质，包括系统性硬化症（SSc）、肝纤维化、慢性肾病、特发性肺纤维化（IPF）和igg4相关疾病（IgG4-RD）。本文综述了目前对纤维化中Tfh细胞生物学的理解，旨在为其参与发病机制提供更深入的见解，并确定潜在的新治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Follicular helper T cells and fibrotic diseases

T follicular helper (Tfh) cells constitute a functionally specialized subset of CD4+ T lymphocytes that orchestrate germinal center (GC) responses, critically regulating B cell destination and the development of long-term humoral immunity. Emerging evidence implicates Tfh cells as key mediators in the pathogenesis of multiple fibrotic disorders across multiple organ systems, including systemic sclerosis (SSc), hepatic fibrosis, chronic kidney disease, idiopathic pulmonary fibrosis (IPF) and IgG4-Related Disease (IgG4-RD). This review synthesizes current understanding of Tfh cell biology in fibrosis, aiming to provide deeper insights into their involvement in pathogenesis and identify potential new therapeutic targets.

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来源期刊

Cellular immunology 生物-免疫学

CiteScore

8.20

自引率

2.30%

发文量

102

审稿时长

30 days

期刊介绍： Cellular Immunology publishes original investigations concerned with the immunological activities of cells in experimental or clinical situations. The scope of the journal encompasses the broad area of in vitro and in vivo studies of cellular immune responses. Purely clinical descriptive studies are not considered. Research Areas include: • Antigen receptor sites • Autoimmunity • Delayed-type hypersensitivity or cellular immunity • Immunologic deficiency states and their reconstitution • Immunologic surveillance and tumor immunity • Immunomodulation • Immunotherapy • Lymphokines and cytokines • Nonantibody immunity • Parasite immunology • Resistance to intracellular microbial and viral infection • Thymus and lymphocyte immunobiology • Transplantation immunology • Tumor immunity.