6兆电子伏电子束和6毫伏光子束的闪光效应及其对体内平均剂量率的依赖

IF 2.7 3区医学 Q3 ONCOLOGY

Clinical and Translational Radiation Oncology Pub Date : 2025-09-23 DOI:10.1016/j.ctro.2025.101052

Salomé Paillas, Edward R.J.F. Taylor, Nathalie Lövgren, Iain D.C. Tullis, Kristoffer Petersson

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引用次数: 0

摘要

本研究表明，平均剂量率的增加延迟了半胸照射后小鼠皮肤辐射毒性的发生，并降低了其严重程度。6毫伏光子和6兆电子伏特电子束辐照后，闪蒸节约效应的大小和对剂量率的依赖性相似。

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Quantifying the flash effect and its dependence on average dose rate in vivo for 6 MeV electron and 6 MV photon beams

This study shows that an increase in average dose rate delays the onset, and reduces the severity, of radiation induced skin toxicity in mice following hemi-thorax irradiation. The FLASH sparing effect’s magnitude and dependence on dose rate appear similar following irradiations using 6 MV photon and 6 MeV electron beams.

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