重症监护病房获得性虚弱患者运动功能和认知功能的恢复

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Journal of critical care Pub Date : 2025-09-27 DOI:10.1016/j.jcrc.2025.155273

Yusuke Aoyama , Masaki Okazaki , Shogo Suzuki , Mako Umikawa , Minoru Hoshiyama

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引用次数: 0

摘要

目的探讨ICU获得性虚弱（ICU- aw）患者出院后日常生活活动（ADLs）恢复的影响因素。方法对65例ICU-AW患者进行回顾性队列研究。数据收集自ICU出院至出院后4周。分析的变量包括年龄、性别、APACHE-II评分、机械通气持续时间和谵妄的存在。主要观察指标为ADL恢复。使用ICU出院时的数据进行多元回归分析，并采用线性混合模型评估运动功能独立测量（FIM）评分的变化。结果中位年龄61岁（IQR: 50-70），女性占44.6%。APACHE-II评分中位数为25分（IQR: 20-29）， 69.2%为外科ICU患者。机械通气时间中位数为19天（IQR: 10-34），谵妄持续时间中位数为3天（IQR: 1-7）。多变量分析显示，ICU出院时认知FIM评分（β = 19.12, p = 0.001）和谵妄持续时间（β = - 9.83, p < 0.001）与ADL恢复独立相关。线性混合模型显示，保留认知功能的患者和认知功能障碍患者的运动FIM增益有显著差异（p = 0.001）。结论ICU出院时认知功能和谵妄持续时间对ADL恢复有显著预测作用。在icu后康复规划中应考虑这些因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Recovery of motor functions and cognitive functions in patients with intensive care unit–acquired weakness

查看原文本刊更多论文

Recovery of motor functions and cognitive functions in patients with intensive care unit–acquired weakness

Purpose

This study aimed to identify factors influencing recovery of activities of daily living (ADLs) in patients with ICU-acquired weakness (ICU-AW) after ICU discharge.

Methods

A retrospective cohort study was conducted with 65 ICU-AW patients. Data were collected from ICU discharge to four weeks post-discharge. Variables analyzed included age, sex, APACHE-II score, mechanical ventilation duration, and presence of delirium. The primary outcome was ADL recovery. Multiple regression analysis was performed using data at ICU discharge, and a linear mixed model assessed changes in motor Functional Independence Measure (FIM) scores.

Results

Median age was 61 years (IQR: 50–70), with females comprising 44.6 %. Median APACHE-II score was 25 (IQR: 20–29), and 69.2 % were surgical ICU patients. Median mechanical ventilation duration was 19 days (IQR: 10–34), and delirium lasted a median of three days (IQR: 1–7). Multivariable analysis showed cognitive FIM score at ICU discharge (β = 19.12, p = 0.001) and delirium duration (β = −9.83, p < 0.001) were independently associated with ADL recovery. The linear mixed model revealed a significant difference in motor FIM gain between patients with preserved cognition and those with cognitive dysfunction (p = 0.001).

Conclusions

Cognitive function at ICU discharge and delirium duration significantly predicted ADL recovery. These factors should be considered in post-ICU rehabilitation planning.

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来源期刊

Journal of critical care 医学-危重病医学

CiteScore

8.60

自引率

2.70%

发文量

237

审稿时长

23 days

期刊介绍： The Journal of Critical Care, the official publication of the World Federation of Societies of Intensive and Critical Care Medicine (WFSICCM), is a leading international, peer-reviewed journal providing original research, review articles, tutorials, and invited articles for physicians and allied health professionals involved in treating the critically ill. The Journal aims to improve patient care by furthering understanding of health systems research and its integration into clinical practice. The Journal will include articles which discuss: All aspects of health services research in critical care System based practice in anesthesiology, perioperative and critical care medicine The interface between anesthesiology, critical care medicine and pain Integrating intraoperative management in preparation for postoperative critical care management and recovery Optimizing patient management, i.e., exploring the interface between evidence-based principles or clinical insight into management and care of complex patients The team approach in the OR and ICU System-based research Medical ethics Technology in medicine Seminars discussing current, state of the art, and sometimes controversial topics in anesthesiology, critical care medicine, and professional education Residency Education.