脂肪来源干细胞的组学特征和表观遗传修饰。

IF 4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Biological Chemistry Pub Date : 2025-09-24 DOI:10.1016/j.jbc.2025.110758

Tiange Feng,Clifford J Rosen,Ziru Li

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引用次数: 0

摘要

脂肪源性干细胞（ADSCs）具有多能分化为多种细胞系，包括脂肪细胞、成骨细胞、神经元和平滑肌细胞，因此在组织再生中显示出巨大的潜力。组学技术的最新进展通过转录组学、蛋白质组学和脂质组学分析增强了我们对ADSC分子谱的理解。此外，在不改变DNA序列的情况下介导基因表达的可遗传变化的表观遗传修饰在ADSC的多谱系分化过程中发挥了关键作用。本文综述了最近在ADSC组学和表观遗传学方面的发现，提供了对其独特属性的最新观点。

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Omics Characteristics and Epigenetic Modifications of Adipose-Derived Stem Cells.

Adipose-derived stem cells (ADSCs) possess multipotency to differentiate into various lineages, including adipocytes, osteoblasts, neurons, and smooth muscle cells, thereby demonstrating significant potential in tissue regeneration. Recent advances in omics technologies have enhanced our understanding of ADSC molecular profiles by transcriptomic, proteomic and lipidomic analysis. Additionally, epigenetic modifications, which mediate heritable changes in gene expression without altering the DNA sequence, play a pivotal role during the multiple lineage differentiation of ADSC. This review presents a summary of recent findings on ADSC omics and epigenetics, offering an updated perspective on their distinct attributes.

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来源期刊

Journal of Biological Chemistry Biochemistry, Genetics and Molecular Biology-Biochemistry

自引率

4.20%

发文量

1233

期刊介绍： The Journal of Biological Chemistry welcomes high-quality science that seeks to elucidate the molecular and cellular basis of biological processes. Papers published in JBC can therefore fall under the umbrellas of not only biological chemistry, chemical biology, or biochemistry, but also allied disciplines such as biophysics, systems biology, RNA biology, immunology, microbiology, neurobiology, epigenetics, computational biology, ’omics, and many more. The outcome of our focus on papers that contribute novel and important mechanistic insights, rather than on a particular topic area, is that JBC is truly a melting pot for scientists across disciplines. In addition, JBC welcomes papers that describe methods that will help scientists push their biochemical inquiries forward and resources that will be of use to the research community.