有价值的萜类风味化合物及其前体在微生物中的可持续生物合成研究进展。

IF 6.1 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biotechnology for Biofuels Pub Date : 2025-09-25 DOI:10.1186/s13068-025-02699-2

Qian Li, Yibo Ning, Deyu Liu, Jie Ren, Changtong Lu, Zhifei Chen, Guanglu Wang

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引用次数: 0

摘要

萜类风味化合物及其前体以其独特的香气而闻名，广泛应用于医药、食品、香料和香料行业。合成生物学的快速发展，包括微生物底盘细胞的修饰，新目标产品合成途径的设计以及大规模微生物发酵的整合，使微生物细胞工厂能够绿色高效地生产萜类风味化合物及其前体，提供了更广阔的市场潜力。本文综述了萜类风味化合物及其前体的生物合成机制、最新研究进展以及提高萜类风味化合物及其前体生物合成效率的策略。本研究旨在支持可持续生产技术的进步，促进香精香料行业的工业应用。

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Advances in the sustainable biosynthesis of valuable terpenoid flavor compounds and precursors in micro-organisms

Renowned for their distinctive aromas, terpenoid flavor compounds and their precursors are widely used in medicine, food, and the flavor and fragrance industries. Rapid advances in synthetic biology, including the modification of microbial chassis cells, the design of synthetic pathways for novel target products, and the integration of large-scale microbial fermentation, have enabled the development of microbial cell factories for the green and efficient production of terpenoid flavor compounds and their precursors, offering broader market potential. This review examines common biosynthetic mechanisms, recent progress in the field, and strategies for enhancing the biosynthetic efficiency of terpenoid flavor compounds and their precursors. This study aims to support the advancements of sustainable production technologies and promote industrial application within the flavor and fragrance sector.

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来源期刊

Biotechnology for Biofuels 工程技术-生物工程与应用微生物

自引率

0.00%

发文量

审稿时长

2.7 months

期刊介绍： Biotechnology for Biofuels is an open access peer-reviewed journal featuring high-quality studies describing technological and operational advances in the production of biofuels, chemicals and other bioproducts. The journal emphasizes understanding and advancing the application of biotechnology and synergistic operations to improve plants and biological conversion systems for the biological production of these products from biomass, intermediates derived from biomass, or CO2, as well as upstream or downstream operations that are integral to biological conversion of biomass. Biotechnology for Biofuels focuses on the following areas: • Development of terrestrial plant feedstocks • Development of algal feedstocks • Biomass pretreatment, fractionation and extraction for biological conversion • Enzyme engineering, production and analysis • Bacterial genetics, physiology and metabolic engineering • Fungal/yeast genetics, physiology and metabolic engineering • Fermentation, biocatalytic conversion and reaction dynamics • Biological production of chemicals and bioproducts from biomass • Anaerobic digestion, biohydrogen and bioelectricity • Bioprocess integration, techno-economic analysis, modelling and policy • Life cycle assessment and environmental impact analysis