不仅仅是一种副产品：V(D)J重组产生的环状DNA分子与b细胞白血病的预后不良有关。

IF 4.5 2区医学 Q1 Biochemistry, Genetics and Molecular Biology

Molecular Oncology Pub Date : 2025-09-25 DOI:10.1002/1878-0261.70134

Davide Pradella, Andrea Ventura

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引用次数: 0

摘要

切除的信号圈（ESC）是T细胞和b细胞成熟过程中产生的环状DNA分子。以前被认为是生物惰性的，Gao等人最近的研究表明，ESCs可以在健康淋巴细胞中复制和积累。此外，作者将高水平的ESCs与b细胞白血病患者复发风险增加联系起来，并提出这种现象是由于ESCs诱导基因组不稳定的独特能力。

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Not just a by-product: circular DNA molecules derived from V(D)J recombination are linked to worse prognosis in B-cell leukemia.

Excised signal circles (ESC) are circular DNA molecules generated during T- and B-cell maturation. Previously considered biologically inert, recent work by Gao et al. now show that ESCs can replicate and accumulate in healthy lymphocytes. Moreover, the authors link higher levels of ESCs to an increased risk of relapse in B-cell leukemia patients and propose that this phenomenon is due to the unique ability of ESCs to induce genome instability.

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来源期刊

Molecular Oncology Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

11.80

自引率

1.50%

发文量

203

审稿时长

10 weeks

期刊介绍： Molecular Oncology highlights new discoveries, approaches, and technical developments, in basic, clinical and discovery-driven translational cancer research. It publishes research articles, reviews (by invitation only), and timely science policy articles. The journal is now fully Open Access with all articles published over the past 10 years freely available.