胸壁黑色素瘤对侧腋窝前哨淋巴结:第一例文献记录和文献回顾。

IF 1.9 4区 医学 Q3 DERMATOLOGY
Luke Davies, Vasileios Skepastianos, Chrysoula Palazi, Georgios Skepastianos
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引用次数: 0

摘要

本病例报告和文献回顾详细介绍了一名69岁男性左胸壁皮肤恶性黑色素瘤对侧腋窝前哨淋巴结阳性的发现。切除活检证实结节性黑色素瘤(Breslow厚度6.6 mm,有丝分裂指数11,无溃疡或微卫星,完全切除,pT4a)。术前淋巴显像发现右腋窝前哨淋巴结。患者接受了2厘米边缘的广泛局部切除和前哨淋巴结活检,未发现疾病扩散。随后是6个周期的辅助派姆单抗,监测扫描仍然清晰。文献回顾发现22例胸壁前黑色素瘤(n = 4)或乳腺癌(n = 18)伴对侧引流(12例报告,2例系列病例,8例回顾性研究)。既往仅有一例胸壁黑色素瘤伴对侧引流,但细节未见报道。因此,我们报告了第一例胸壁前黑素瘤伴对侧前哨淋巴结的病例,并强调了对意外引流模式的可疑病变进行全面评估的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Contralateral axillary sentinel lymph node in chest wall melanoma: first documented case and narrative review of the literature.

This case report and literature review detail and contextualise the finding of a positive sentinel node in the contralateral axilla of a 69-year-old male with cutaneous malignant melanoma of the left chest wall. Excision biopsy confirmed nodular melanoma (Breslow thickness 6.6 mm; mitotic index 11; no ulceration or microsatellites; completely excised; pT4a). Preoperative lymphoscintigraphy identified the sentinel node in the right axilla. The patient underwent wide local excision with 2-cm margins and a sentinel lymph node biopsy, which showed no spread of disease. This was followed by six cycles of adjuvant pembrolizumab with surveillance scans remaining clear. Literature review identified 22 cases of anterior chest wall melanoma (n = 4) or breast carcinoma (n = 18) with contralateral drainage (12 case reports, two case series, and eight retrospective studies). Only one previous chest wall melanoma case with contralateral drainage was identified, but details were not reported. Thus, we present the first documented case of anterior chest wall melanoma with a contralateral sentinel node, and emphasise the importance of thorough evaluation of suspicious lesions for unexpected drainage patterns.

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来源期刊
Melanoma Research
Melanoma Research 医学-皮肤病学
CiteScore
3.40
自引率
4.50%
发文量
139
审稿时长
6-12 weeks
期刊介绍: ​​​​​​Melanoma Research is a well established international forum for the dissemination of new findings relating to melanoma. The aim of the Journal is to promote the level of informational exchange between those engaged in the field. Melanoma Research aims to encourage an informed and balanced view of experimental and clinical research and extend and stimulate communication and exchange of knowledge between investigators with differing areas of expertise. This will foster the development of translational research. The reporting of new clinical results and the effect and toxicity of new therapeutic agents and immunotherapy will be given emphasis by rapid publication of Short Communications. ​Thus, Melanoma Research seeks to present a coherent and up-to-date account of all aspects of investigations pertinent to melanoma. Consequently the scope of the Journal is broad, embracing the entire range of studies from fundamental and applied research in such subject areas as genetics, molecular biology, biochemistry, cell biology, photobiology, pathology, immunology, and advances in clinical oncology influencing the prevention, diagnosis and treatment of melanoma.
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