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引用次数: 0
摘要
背景：鼻给药提供了一种非侵入性的途径，具有快速吸收和绕过第一过代谢的能力，通过靶向给药和穿越血脑屏障，使其有望用于中枢神经系统（CNS）疾病、变应性鼻炎等鼻腔疾病和其他慢性疾病。目的：综述鼻腔给药的优点，天然产物的治疗潜力，以及药物给药系统如何克服生物利用度和溶解度问题。研究设计：通过文献综述分析天然药物鼻腔给药的机制、临床应用和局限性。方法：从谷歌Scholar、PubMed、ScienceDirect、Scopus、Web of Science、施普林格和官方来源检索2025年1月前发表的相关文章。结果：鼻给药提高天然产物的生物利用度和吸收，增强抗炎、抗氧化、神经保护和抗过敏作用。然而，较差的溶解度和稳定性仍然是障碍，这可以通过纳米载体、脂质体和其他先进的系统来缓解。结论：鼻给药联合天然药物是治疗中枢神经系统、鼻腔和慢性疾病的一种有前景的策略，可能提高临床疗效并扩大治疗选择。
Advancements in nasal drug delivery system of natural products.
Background: Nasal drug delivery offers a non-invasive route with rapid absorption and the ability to bypass first-pass metabolism, making it promising for central nervous system (CNS) disorders, nasal diseases such as allergic rhinitis, and other chronic conditions by enabling targeted delivery and crossing the blood-brain barrier.
Purpose: To review the advantages of nasal delivery, therapeutic potential of natural products, and how drug delivery systems may overcome bioavailability and solubility issues.
Study design: A literature review analyzing mechanisms, clinical applications, and limitations of natural products in nasal delivery.
Methods: Relevant articles published before January 2025 were retrieved from Google Scholar, PubMed, ScienceDirect, Scopus, Web of Science, Springer, and official sources.
Results: Nasal administration improves the bioavailability and absorption of natural products, enhancing anti-inflammatory, antioxidant, neuroprotective, and anti-allergic effects. However, poor solubility and stability remain barriers, which may be mitigated by nanocarriers, liposomes, and other advanced systems.
Conclusion: Combining nasal drug delivery with natural products is a promising strategy for treating CNS, nasal, and chronic diseases, potentially improving clinical efficacy and expanding therapeutic options.
期刊介绍：
Frontiers in Pharmacology is a leading journal in its field, publishing rigorously peer-reviewed research across disciplines, including basic and clinical pharmacology, medicinal chemistry, pharmacy and toxicology. Field Chief Editor Heike Wulff at UC Davis is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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