病例评论：成功使用奥洛芬治疗多药耐药的儿童增殖性绵孢菌感染。

IF 4.5 2区医学 Q2 MICROBIOLOGY

Antimicrobial Agents and Chemotherapy Pub Date : 2025-09-26 DOI:10.1128/aac.01072-25

Nathan P Wiederhold

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引用次数: 0

摘要

增殖性绵孢菌是一种多重耐药丝状真菌，可在免疫功能低下和免疫功能正常的宿主中引起侵袭性疾病。目前的治疗方案有限。Olorofim是一种正在研究的抗真菌药物，它对几种不同的霉菌有活性，包括许多对其他抗真菌药物有抗性的霉菌。Fortini等人介绍的病例（抗菌药物Chemother 69:e00602- 25,2025, https://doi.org/10.1128/aac.00602-25）描述了一名患有增殖性卷孢菌肌腱炎、滑膜炎和骨髓炎的8岁儿童成功使用色罗菲姆治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Case Commentary: Successful use of olorofim for the treatment of multi-drug-resistant Lomentospora prolificans infection in a child.

Lomentospora prolificans is a multi-drug-resistant filamentous fungus that can cause invasive disease in both immunocompromised and immunocompetent hosts. Current treatment options are limited. Olorofim is an investigational antifungal that demonstrates activity against several different molds, including many that are resistant to other antifungals. The case presented by Fortini et al. (Antimicrob Agents Chemother 69:e00602-25, 2025, https://doi.org/10.1128/aac.00602-25) describes the successful use of olorofim treatment in an 8-year-old who suffered from Lomentospora prolificans tendonitis, synovitis, and osteomyelitis.

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来源期刊

Antimicrobial Agents and Chemotherapy 医学-微生物学

CiteScore

10.00

自引率

8.20%

发文量

762

审稿时长

3 months

期刊介绍： Antimicrobial Agents and Chemotherapy (AAC) features interdisciplinary studies that build our understanding of the underlying mechanisms and therapeutic applications of antimicrobial and antiparasitic agents and chemotherapy.