Chih-Chiang Chang, Balaji Selvaraj, Xingyi Zhao, Jacob Rembish, Paige A. Taylor, Alexander Bookbinder, Chingyun Cheng, J. Isabelle Choi, Charles B. Simone II, Haibo Lin, Minglei Kang
{"title":"首次第三方验证经验：质子FLASH交付的可靠校准和质量保证程序","authors":"Chih-Chiang Chang, Balaji Selvaraj, Xingyi Zhao, Jacob Rembish, Paige A. Taylor, Alexander Bookbinder, Chingyun Cheng, J. Isabelle Choi, Charles B. Simone II, Haibo Lin, Minglei Kang","doi":"10.1002/acm2.70269","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Proton FLASH radiotherapy, delivering ultra-high dose rates, shows promise in reducing normal tissue toxicity while maintaining tumor control. However, accurate dosimetry and quality assurance (QA) for FLASH remain challenging due to the extreme dose rates involved. Developing reliable calibration and QA procedures is crucial for advancing FLASH towards clinical implementation.</p>\n </section>\n \n <section>\n \n <h3> Purpose</h3>\n \n <p>To present an effective routine calibration and QA procedure for proton FLASH delivery to ensure high-quality dosimetry performance for preclinical and clinical delivery.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A high temporospatial resolution strip ionization chamber array (SICA) detector was mounted to the treatment nozzle, which was calibrated using an Advanced Markus ion chamber (IC) under variable dose and ultra-high dose rates. The calibration curve was used to monitor the delivery in real-time. The maximum beam current was 215 nA at the isocenter at the highest energy of the cyclotron (250 MeV). Third-party IROC (Imaging and Radiation Oncology Core) thermoluminescent dosimeters (TLDs) were requested to verify the accuracy and effectiveness of the calibration and validation procedure. A transmission field with a field size of 3 × 3 cm<sup>2</sup> was designed to deliver 2000 cGy doses with a field-averaged dose rate varying from 36 to 76.5 Gy/s.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The entire calibration process took less than 10 minutes as part of routine daily QA. The calibration curve between the SICA detector and IC demonstrated an <i>R</i>-value of almost 1.00. The SICA detector measured each delivery, providing critical data for FLASH analysis, including field size, dose, delivery time, and dose rate. Based on real-time dose and dose rate monitoring, the planned and delivered doses were within 1% accuracy according to third-party TLD measurements.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>As demonstrated by IROC measurements, effective calibration and QA using a SICA detector for proton FLASH delivery can ensure high accuracy in real-time dose and dose rate monitoring, paving the way for future clinical applications.</p>\n </section>\n </div>","PeriodicalId":14989,"journal":{"name":"Journal of Applied Clinical Medical Physics","volume":"26 10","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://aapm.onlinelibrary.wiley.com/doi/epdf/10.1002/acm2.70269","citationCount":"0","resultStr":"{\"title\":\"First experience with third-party validations: A robust calibration and QA procedure for proton FLASH delivery\",\"authors\":\"Chih-Chiang Chang, Balaji Selvaraj, Xingyi Zhao, Jacob Rembish, Paige A. Taylor, Alexander Bookbinder, Chingyun Cheng, J. Isabelle Choi, Charles B. Simone II, Haibo Lin, Minglei Kang\",\"doi\":\"10.1002/acm2.70269\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Proton FLASH radiotherapy, delivering ultra-high dose rates, shows promise in reducing normal tissue toxicity while maintaining tumor control. However, accurate dosimetry and quality assurance (QA) for FLASH remain challenging due to the extreme dose rates involved. Developing reliable calibration and QA procedures is crucial for advancing FLASH towards clinical implementation.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Purpose</h3>\\n \\n <p>To present an effective routine calibration and QA procedure for proton FLASH delivery to ensure high-quality dosimetry performance for preclinical and clinical delivery.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>A high temporospatial resolution strip ionization chamber array (SICA) detector was mounted to the treatment nozzle, which was calibrated using an Advanced Markus ion chamber (IC) under variable dose and ultra-high dose rates. The calibration curve was used to monitor the delivery in real-time. The maximum beam current was 215 nA at the isocenter at the highest energy of the cyclotron (250 MeV). Third-party IROC (Imaging and Radiation Oncology Core) thermoluminescent dosimeters (TLDs) were requested to verify the accuracy and effectiveness of the calibration and validation procedure. A transmission field with a field size of 3 × 3 cm<sup>2</sup> was designed to deliver 2000 cGy doses with a field-averaged dose rate varying from 36 to 76.5 Gy/s.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The entire calibration process took less than 10 minutes as part of routine daily QA. The calibration curve between the SICA detector and IC demonstrated an <i>R</i>-value of almost 1.00. The SICA detector measured each delivery, providing critical data for FLASH analysis, including field size, dose, delivery time, and dose rate. Based on real-time dose and dose rate monitoring, the planned and delivered doses were within 1% accuracy according to third-party TLD measurements.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>As demonstrated by IROC measurements, effective calibration and QA using a SICA detector for proton FLASH delivery can ensure high accuracy in real-time dose and dose rate monitoring, paving the way for future clinical applications.</p>\\n </section>\\n </div>\",\"PeriodicalId\":14989,\"journal\":{\"name\":\"Journal of Applied Clinical Medical Physics\",\"volume\":\"26 10\",\"pages\":\"\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-09-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://aapm.onlinelibrary.wiley.com/doi/epdf/10.1002/acm2.70269\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Applied Clinical Medical Physics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://aapm.onlinelibrary.wiley.com/doi/10.1002/acm2.70269\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Applied Clinical Medical Physics","FirstCategoryId":"3","ListUrlMain":"https://aapm.onlinelibrary.wiley.com/doi/10.1002/acm2.70269","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
First experience with third-party validations: A robust calibration and QA procedure for proton FLASH delivery
Background
Proton FLASH radiotherapy, delivering ultra-high dose rates, shows promise in reducing normal tissue toxicity while maintaining tumor control. However, accurate dosimetry and quality assurance (QA) for FLASH remain challenging due to the extreme dose rates involved. Developing reliable calibration and QA procedures is crucial for advancing FLASH towards clinical implementation.
Purpose
To present an effective routine calibration and QA procedure for proton FLASH delivery to ensure high-quality dosimetry performance for preclinical and clinical delivery.
Methods
A high temporospatial resolution strip ionization chamber array (SICA) detector was mounted to the treatment nozzle, which was calibrated using an Advanced Markus ion chamber (IC) under variable dose and ultra-high dose rates. The calibration curve was used to monitor the delivery in real-time. The maximum beam current was 215 nA at the isocenter at the highest energy of the cyclotron (250 MeV). Third-party IROC (Imaging and Radiation Oncology Core) thermoluminescent dosimeters (TLDs) were requested to verify the accuracy and effectiveness of the calibration and validation procedure. A transmission field with a field size of 3 × 3 cm2 was designed to deliver 2000 cGy doses with a field-averaged dose rate varying from 36 to 76.5 Gy/s.
Results
The entire calibration process took less than 10 minutes as part of routine daily QA. The calibration curve between the SICA detector and IC demonstrated an R-value of almost 1.00. The SICA detector measured each delivery, providing critical data for FLASH analysis, including field size, dose, delivery time, and dose rate. Based on real-time dose and dose rate monitoring, the planned and delivered doses were within 1% accuracy according to third-party TLD measurements.
Conclusion
As demonstrated by IROC measurements, effective calibration and QA using a SICA detector for proton FLASH delivery can ensure high accuracy in real-time dose and dose rate monitoring, paving the way for future clinical applications.
期刊介绍：
Journal of Applied Clinical Medical Physics is an international Open Access publication dedicated to clinical medical physics. JACMP welcomes original contributions dealing with all aspects of medical physics from scientists working in the clinical medical physics around the world. JACMP accepts only online submission.
JACMP will publish:
-Original Contributions: Peer-reviewed, investigations that represent new and significant contributions to the field. Recommended word count: up to 7500.
-Review Articles: Reviews of major areas or sub-areas in the field of clinical medical physics. These articles may be of any length and are peer reviewed.
-Technical Notes: These should be no longer than 3000 words, including key references.
-Letters to the Editor: Comments on papers published in JACMP or on any other matters of interest to clinical medical physics. These should not be more than 1250 (including the literature) and their publication is only based on the decision of the editor, who occasionally asks experts on the merit of the contents.
-Book Reviews: The editorial office solicits Book Reviews.
-Announcements of Forthcoming Meetings: The Editor may provide notice of forthcoming meetings, course offerings, and other events relevant to clinical medical physics.
-Parallel Opposed Editorial: We welcome topics relevant to clinical practice and medical physics profession. The contents can be controversial debate or opposed aspects of an issue. One author argues for the position and the other against. Each side of the debate contains an opening statement up to 800 words, followed by a rebuttal up to 500 words. Readers interested in participating in this series should contact the moderator with a proposed title and a short description of the topic
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
