生物系统中的六氟环氧丙烷三聚羧酸

IF 3.3 4区医学 Q2 PHARMACOLOGY & PHARMACY

Basic & Clinical Pharmacology & Toxicology Pub Date : 2025-09-27 DOI:10.1111/bcpt.70117

Bei Yang, Jie Liu

{"title":"生物系统中的六氟环氧丙烷三聚羧酸","authors":"Bei Yang, Jie Liu","doi":"10.1111/bcpt.70117","DOIUrl":null,"url":null,"abstract":"<p>As a replacement for phased-out perfluorooctanoic acid (PFOA), hexafluoropropylene oxide trimer carboxylic acid (HFPO-TA) exhibits environmental persistence and multisystem toxicity, affecting reproductive, hepatic, neurological and endocrine functions. Despite its industrial adoption, emerging studies reveal bioaccumulation risks and mechanistic toxicity through oxidative stress, metabolic disruption and inflammation. This review synthesizes evidence of HFPO-TA's health impacts, highlighting unresolved female reproductive toxicity and dose–response relationships.</p>","PeriodicalId":8733,"journal":{"name":"Basic & Clinical Pharmacology & Toxicology","volume":"137 5","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bcpt.70117","citationCount":"0","resultStr":"{\"title\":\"Hexafluoropropylene Oxide Trimer Carboxylic Acid in Biological Systems\",\"authors\":\"Bei Yang, Jie Liu\",\"doi\":\"10.1111/bcpt.70117\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>As a replacement for phased-out perfluorooctanoic acid (PFOA), hexafluoropropylene oxide trimer carboxylic acid (HFPO-TA) exhibits environmental persistence and multisystem toxicity, affecting reproductive, hepatic, neurological and endocrine functions. Despite its industrial adoption, emerging studies reveal bioaccumulation risks and mechanistic toxicity through oxidative stress, metabolic disruption and inflammation. This review synthesizes evidence of HFPO-TA's health impacts, highlighting unresolved female reproductive toxicity and dose–response relationships.</p>\",\"PeriodicalId\":8733,\"journal\":{\"name\":\"Basic & Clinical Pharmacology & Toxicology\",\"volume\":\"137 5\",\"pages\":\"\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-09-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bcpt.70117\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Basic & Clinical Pharmacology & Toxicology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/bcpt.70117\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Basic & Clinical Pharmacology & Toxicology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/bcpt.70117","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}

引用次数: 0

摘要

作为逐步淘汰的全氟辛酸（PFOA）的替代品，六氟环氧丙烷三聚羧酸（HFPO-TA）具有环境持久性和多系统毒性，影响生殖、肝脏、神经和内分泌功能。尽管它在工业上得到了应用，但新兴的研究表明，氧化应激、代谢破坏和炎症会带来生物积累风险和机械毒性。本综述综合了HFPO-TA对健康影响的证据，强调了尚未解决的女性生殖毒性和剂量-反应关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Hexafluoropropylene Oxide Trimer Carboxylic Acid in Biological Systems

查看原文本刊更多论文

Hexafluoropropylene Oxide Trimer Carboxylic Acid in Biological Systems

As a replacement for phased-out perfluorooctanoic acid (PFOA), hexafluoropropylene oxide trimer carboxylic acid (HFPO-TA) exhibits environmental persistence and multisystem toxicity, affecting reproductive, hepatic, neurological and endocrine functions. Despite its industrial adoption, emerging studies reveal bioaccumulation risks and mechanistic toxicity through oxidative stress, metabolic disruption and inflammation. This review synthesizes evidence of HFPO-TA's health impacts, highlighting unresolved female reproductive toxicity and dose–response relationships.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Basic & Clinical Pharmacology & Toxicology 医学-毒理学

CiteScore

5.60

自引率

6.50%

发文量

126

审稿时长

1 months

期刊介绍： Basic & Clinical Pharmacology and Toxicology is an independent journal, publishing original scientific research in all fields of toxicology, basic and clinical pharmacology. This includes experimental animal pharmacology and toxicology and molecular (-genetic), biochemical and cellular pharmacology and toxicology. It also includes all aspects of clinical pharmacology: pharmacokinetics, pharmacodynamics, therapeutic drug monitoring, drug/drug interactions, pharmacogenetics/-genomics, pharmacoepidemiology, pharmacovigilance, pharmacoeconomics, randomized controlled clinical trials and rational pharmacotherapy. For all compounds used in the studies, the chemical constitution and composition should be known, also for natural compounds.