活跃星形胶质细胞:钙动力学、电路调制和干预目标

IF 3.8 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Dmitri A. Rusakov, Thomas P. Jensen, Olga Tyurikova
{"title":"活跃星形胶质细胞:钙动力学、电路调制和干预目标","authors":"Dmitri A. Rusakov,&nbsp;Thomas P. Jensen,&nbsp;Olga Tyurikova","doi":"10.1007/s11064-025-04553-1","DOIUrl":null,"url":null,"abstract":"<div><p>Astrocytes, once considered passive support cells, have emerged as active participants in synaptic communication through Ca<sup>2+</sup>-dependent molecular signalling often referred to as gliotransmission. This review highlights the pioneering contributions of Giorgio Carmignoto, whose work has helped to redefine astrocytes as integral components of the tripartite synapse. Central to this paradigm shift is the role of astrocytic Ca²⁺ signalling in modulating synaptic activity, plasticity, and network behaviour. Carmignoto’s research demonstrated that intracellular Ca<sup>2+</sup> fluctuations in astrocytes trigger the release of signalling molecules, influencing both excitatory and inhibitory neuronal circuits. These discoveries extended to network-level phenomena, implicating astrocytic Ca<sup>2+</sup> waves in pathological states like epilepsy. Technologically, Carmignoto advanced astroglial research by employing genetically encoded calcium indicators, optogenetic tools, and cutting-edge imaging methods, including multi-photon microscopy, to observe astrocyte activity in vivo. His work also contributed to automated data analysis pipelines that uncover fine-scale astrocytic microdomain dynamics. In the context of pathology, Carmignoto’s studies related astrocytic dysfunction to epilepsy and dopaminergic dysregulation, suggesting new therapeutic avenues through astrocyte-specific interventions. Despite these advances, challenges remain in defining gliotransmitter mechanisms, understanding astrocyte heterogeneity, and developing tools for precise functional manipulation.</p></div>","PeriodicalId":719,"journal":{"name":"Neurochemical Research","volume":"50 5","pages":""},"PeriodicalIF":3.8000,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11064-025-04553-1.pdf","citationCount":"0","resultStr":"{\"title\":\"The Active Astrocyte: Calcium Dynamics, Circuit Modulation, and Targets for Intervention\",\"authors\":\"Dmitri A. Rusakov,&nbsp;Thomas P. Jensen,&nbsp;Olga Tyurikova\",\"doi\":\"10.1007/s11064-025-04553-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Astrocytes, once considered passive support cells, have emerged as active participants in synaptic communication through Ca<sup>2+</sup>-dependent molecular signalling often referred to as gliotransmission. This review highlights the pioneering contributions of Giorgio Carmignoto, whose work has helped to redefine astrocytes as integral components of the tripartite synapse. Central to this paradigm shift is the role of astrocytic Ca²⁺ signalling in modulating synaptic activity, plasticity, and network behaviour. Carmignoto’s research demonstrated that intracellular Ca<sup>2+</sup> fluctuations in astrocytes trigger the release of signalling molecules, influencing both excitatory and inhibitory neuronal circuits. These discoveries extended to network-level phenomena, implicating astrocytic Ca<sup>2+</sup> waves in pathological states like epilepsy. Technologically, Carmignoto advanced astroglial research by employing genetically encoded calcium indicators, optogenetic tools, and cutting-edge imaging methods, including multi-photon microscopy, to observe astrocyte activity in vivo. His work also contributed to automated data analysis pipelines that uncover fine-scale astrocytic microdomain dynamics. In the context of pathology, Carmignoto’s studies related astrocytic dysfunction to epilepsy and dopaminergic dysregulation, suggesting new therapeutic avenues through astrocyte-specific interventions. Despite these advances, challenges remain in defining gliotransmitter mechanisms, understanding astrocyte heterogeneity, and developing tools for precise functional manipulation.</p></div>\",\"PeriodicalId\":719,\"journal\":{\"name\":\"Neurochemical Research\",\"volume\":\"50 5\",\"pages\":\"\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2025-09-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s11064-025-04553-1.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurochemical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11064-025-04553-1\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurochemical Research","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s11064-025-04553-1","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

星形胶质细胞,曾经被认为是被动的支持细胞,已经成为积极的参与者在突触通信通过Ca2+依赖的分子信号通常被称为胶质传递。这篇综述强调了Giorgio Carmignoto的开创性贡献,他的工作有助于重新定义星形胶质细胞作为三方突触的组成部分。这种模式转变的核心是星形细胞Ca 2 +信号在调节突触活动、可塑性和网络行为中的作用。Carmignoto的研究表明,星形胶质细胞内Ca2+的波动触发信号分子的释放,影响兴奋性和抑制性神经元回路。这些发现延伸到网络水平的现象,暗示星形细胞Ca2+波在病理状态,如癫痫。在技术上,Carmignoto通过使用遗传编码钙指标、光遗传学工具和尖端成像方法(包括多光子显微镜)来观察星形胶质细胞在体内的活性,从而推进了星形胶质研究。他的工作也有助于自动化数据分析管道,揭示精细尺度星形细胞微域动力学。在病理学方面,Carmignoto的研究将星形细胞功能障碍与癫痫和多巴胺能失调联系起来,提出了星形细胞特异性干预的新治疗途径。尽管取得了这些进展,但在确定胶质递质机制、理解星形胶质细胞异质性和开发精确功能操作工具方面仍然存在挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Active Astrocyte: Calcium Dynamics, Circuit Modulation, and Targets for Intervention

Astrocytes, once considered passive support cells, have emerged as active participants in synaptic communication through Ca2+-dependent molecular signalling often referred to as gliotransmission. This review highlights the pioneering contributions of Giorgio Carmignoto, whose work has helped to redefine astrocytes as integral components of the tripartite synapse. Central to this paradigm shift is the role of astrocytic Ca²⁺ signalling in modulating synaptic activity, plasticity, and network behaviour. Carmignoto’s research demonstrated that intracellular Ca2+ fluctuations in astrocytes trigger the release of signalling molecules, influencing both excitatory and inhibitory neuronal circuits. These discoveries extended to network-level phenomena, implicating astrocytic Ca2+ waves in pathological states like epilepsy. Technologically, Carmignoto advanced astroglial research by employing genetically encoded calcium indicators, optogenetic tools, and cutting-edge imaging methods, including multi-photon microscopy, to observe astrocyte activity in vivo. His work also contributed to automated data analysis pipelines that uncover fine-scale astrocytic microdomain dynamics. In the context of pathology, Carmignoto’s studies related astrocytic dysfunction to epilepsy and dopaminergic dysregulation, suggesting new therapeutic avenues through astrocyte-specific interventions. Despite these advances, challenges remain in defining gliotransmitter mechanisms, understanding astrocyte heterogeneity, and developing tools for precise functional manipulation.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Neurochemical Research
Neurochemical Research 医学-神经科学
CiteScore
7.70
自引率
2.30%
发文量
320
审稿时长
6 months
期刊介绍: Neurochemical Research is devoted to the rapid publication of studies that use neurochemical methodology in research on nervous system structure and function. The journal publishes original reports of experimental and clinical research results, perceptive reviews of significant problem areas in the neurosciences, brief comments of a methodological or interpretive nature, and research summaries conducted by leading scientists whose works are not readily available in English.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信