1,3-重氮金刚烷环和螺环衍生物的合成及其嗜神经活性

IF 0.9 4区化学 Q4 CHEMISTRY, ORGANIC

Russian Journal of Organic Chemistry Pub Date : 2025-07-11 DOI:10.1134/S1234567825601330

M. V. Galstyan, A. D. Harutyunyan, K. A. Gevorkyan, M. V. Aleksanyan, I. M. Nazaryan, R. G. Paronikyan, S. P. Gasparyan

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引用次数: 0

摘要

以取代的3,7-重氮杂环壬烷[3.3.1]与环、杂环醛和酮缩合为原料，合成了环和螺环1,3-重氮杂烷衍生物。对促神经活性的筛选表明，螺环1,3-重氮adamantanes比其环类似物表现出更高的效力，活性水平分别为40 - 60%和20-40%。

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Synthesis and Neurotropic Activity of Cyclic and Spirocyclic Derivatives of 1,3-Diazadamantane

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Synthesis and Neurotropic Activity of Cyclic and Spirocyclic Derivatives of 1,3-Diazadamantane

Cyclic and spirocyclic 1,3-diazaadamantane derivatives were synthesized by the condensation of substituted 3,7-diazabicyclo[3.3.1]nonanes with cyclic and heterocyclic aldehydes and ketones. Screening for neurotropic activity showed that spirocyclic 1,3-diazaadamantanes exhibit a higher potency than their cyclic analogs, with activity levels of 40–60 against 20–40%, respectively.

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来源期刊

Russian Journal of Organic Chemistry 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

139

审稿时长

3-6 weeks

期刊介绍： Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.