{"title":"新生儿血浆p-tau217升高：发育信号还是突触应激标志物？","authors":"Caterina Motta, Chiara Giuseppina Bonomi, Alessandro Martorana","doi":"10.1093/braincomms/fcaf335","DOIUrl":null,"url":null,"abstract":"<p><p>The finding of elevated plasma p-tau217 in newborns raises the question of whether it represents a developmental signal or an early marker of synaptic stress, offering new insights into the biology of tau in the human brain.</p>","PeriodicalId":93915,"journal":{"name":"Brain communications","volume":"7 5","pages":"fcaf335"},"PeriodicalIF":4.5000,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455416/pdf/","citationCount":"0","resultStr":"{\"title\":\"Elevated plasma p-tau217 in newborns: developmental signal or synaptic stress marker?\",\"authors\":\"Caterina Motta, Chiara Giuseppina Bonomi, Alessandro Martorana\",\"doi\":\"10.1093/braincomms/fcaf335\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The finding of elevated plasma p-tau217 in newborns raises the question of whether it represents a developmental signal or an early marker of synaptic stress, offering new insights into the biology of tau in the human brain.</p>\",\"PeriodicalId\":93915,\"journal\":{\"name\":\"Brain communications\",\"volume\":\"7 5\",\"pages\":\"fcaf335\"},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2025-09-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455416/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Brain communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/braincomms/fcaf335\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/braincomms/fcaf335","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Elevated plasma p-tau217 in newborns: developmental signal or synaptic stress marker?
The finding of elevated plasma p-tau217 in newborns raises the question of whether it represents a developmental signal or an early marker of synaptic stress, offering new insights into the biology of tau in the human brain.
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