一种使用骨质疏松启发t评分法筛查骨骼肌减少症的新方法。

IF 2.8 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Hyun Sik Kim, Choon Hee Chung, Jung Woo Lee
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引用次数: 0

摘要

目的:肌少症以肌肉质量、力量减少、身体功能受损为特征,需要有效的指标进行早期发现。本研究介绍了一种新的筛选方法,使用预期肌肉功能(eMF)指标和骨质疏松诱导t评分。材料和方法:该模型由来自韩国国家健康和营养调查(KNHANES)的4052个人开发,并由来自韩国基因组和流行病学研究(KoGES)的888个人验证。eMF采用基于握力、体重指数(BMI)、腰围和年龄的logistic回归计算。t得分是通过将eMF与年轻人(20-29岁)的平均值和标准差进行标准化而得出的。t分数临界值在核密度估计图的交叉点确定,男性设为-1.1,女性设为-1.8。低于这些临界值的个体被诊断为肌肉减少症。结果:性能指标是根据肌肉减少症计算的,使用握力和肌肉质量的临界值来定义。该模型性能可靠,灵敏度为0.900,特异度为0.889,准确度为0.890,受试者工作特征曲线下面积为0.932。假阴性表现出与肌肉减少性肥胖相似的临床特征,而假阳性则与可能的肌肉减少症相似。结论:基于emf的指标显著改善了骨骼肌减少症的筛查,能够更准确地识别并支持疾病的早期发现和管理,最终提高患者的治疗效果和医疗服务。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Novel Sarcopenia Screening Approach Using an Osteoporosis-Inspired T-Score Method.

Purpose: Sarcopenia is characterized by reduced muscle mass, strength, and impaired physical function, and it requires effective indicators for early detection. This study introduces a novel screening method using the expected muscle functionality (eMF) indicator and an osteoporosis-inspired T-score.

Materials and methods: The model was developed using 4052 individuals from the Korea National Health and Nutrition Examination Survey (KNHANES) and validated with 888 individuals from the Korean Genome and Epidemiology Study (KoGES). eMF was calculated using logistic regression based on grip strength, body mass index (BMI), waist circumference, and age. The T-score was derived by standardizing eMF against the mean and standard deviation of young adults (aged 20-29 years). The T-score cut-off values were determined at the intersection of kernel density estimation plots, set at -1.1 for men and -1.8 for women. Sarcopenia was diagnosed in individuals below these cutoffs.

Results: Performance metrics were calculated based on sarcopenia defined using cutoff values of grip strength and muscle mass. The model demonstrated reliable performance, with sensitivity, specificity, accuracy, and area under the receiver operating characteristic curve of 0.900, 0.889, 0.890, and 0.932, respectively. False negatives exhibited clinical characteristics similar to sarcopenic obesity, while false positives resembled possible sarcopenia.

Conclusion: The eMF-based indicator offers a significant improvement in sarcopenia screening, enabling more accurate identification and supporting early detection and management of the condition, ultimately enhancing patient outcomes and healthcare delivery.

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来源期刊
Yonsei Medical Journal
Yonsei Medical Journal 医学-医学:内科
CiteScore
4.50
自引率
0.00%
发文量
167
审稿时长
3 months
期刊介绍: The goal of the Yonsei Medical Journal (YMJ) is to publish high quality manuscripts dedicated to clinical or basic research. Any authors affiliated with an accredited biomedical institution may submit manuscripts of original articles, review articles, case reports, brief communications, and letters to the Editor.
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