Graves眼病患者眼压与甲状腺功能正相关:三方面证据分析。

IF 2.8 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Wenhua Zhang, Feng Zhang, Ziyi Zhu, Jiamin Cao, Wei Xiong
{"title":"Graves眼病患者眼压与甲状腺功能正相关:三方面证据分析。","authors":"Wenhua Zhang, Feng Zhang, Ziyi Zhu, Jiamin Cao, Wei Xiong","doi":"10.3349/ymj.2024.0468","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>High intraocular pressure (IOP) is a frequent clinical manifestation of Graves' ophthalmopathy (GO), but little is known about the mechanism by which thyroid function alters IOP in GO.</p><p><strong>Materials and methods: </strong>The relationships between IOP and clinical manifestations of GO were determined by simple linear correlation analysis and the Kruskal-Wallis test. Factors significantly associated with changes in IOP were evaluated by multiple linear regression analysis. The relationships between IOP and thyroid function were verified using data from the National Health and Nutrition Examination Survey, and causative relationships between thyroid function and IOP were assessed using summary-data-based Mendelian randomization analysis. Gene expression was compared in patients with and without GO using analysis of a Gene Expression Omnibus dataset, and associated GO pathways were identified.</p><p><strong>Results: </strong>Clinical data were obtained from 392 hospitalizations of 270 patients, including 142 hospitalizations with increased IOP and 250 with normal IOP. IOP was linearly associated with GO duration, clinical activity score (CAS), and concentrations of free triiodothyronine (FT3), free thyroxine (FT4), and thyrotropin receptor antibodies. Multiple linear regression analysis yielded a model including CAS, FT3 concentration, and sex (r=0.46). Analysis of 3848 samples from the dataset showed that FT3 and FT4 levels differed between the increased and normal IOP groups. Increased expression of the <i>LOXL-AS1</i> gene was identified as a contributor to increased IOP, with <i>LOXL-AS1</i> expression increased in GO.</p><p><strong>Conclusion: </strong>Increased thyroid function is a risk factor for elevated IOP in patients with GO, with higher expression of <i>LOXL-AS1</i> in GO contributing to this effect.</p>","PeriodicalId":23765,"journal":{"name":"Yonsei Medical Journal","volume":"66 10","pages":"675-684"},"PeriodicalIF":2.8000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479196/pdf/","citationCount":"0","resultStr":"{\"title\":\"Positive Relationships between Intraocular Pressure and Thyroid Function in Graves' Ophthalmopathy: A Three-Aspect Evidence Analysis.\",\"authors\":\"Wenhua Zhang, Feng Zhang, Ziyi Zhu, Jiamin Cao, Wei Xiong\",\"doi\":\"10.3349/ymj.2024.0468\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>High intraocular pressure (IOP) is a frequent clinical manifestation of Graves' ophthalmopathy (GO), but little is known about the mechanism by which thyroid function alters IOP in GO.</p><p><strong>Materials and methods: </strong>The relationships between IOP and clinical manifestations of GO were determined by simple linear correlation analysis and the Kruskal-Wallis test. Factors significantly associated with changes in IOP were evaluated by multiple linear regression analysis. The relationships between IOP and thyroid function were verified using data from the National Health and Nutrition Examination Survey, and causative relationships between thyroid function and IOP were assessed using summary-data-based Mendelian randomization analysis. Gene expression was compared in patients with and without GO using analysis of a Gene Expression Omnibus dataset, and associated GO pathways were identified.</p><p><strong>Results: </strong>Clinical data were obtained from 392 hospitalizations of 270 patients, including 142 hospitalizations with increased IOP and 250 with normal IOP. IOP was linearly associated with GO duration, clinical activity score (CAS), and concentrations of free triiodothyronine (FT3), free thyroxine (FT4), and thyrotropin receptor antibodies. Multiple linear regression analysis yielded a model including CAS, FT3 concentration, and sex (r=0.46). Analysis of 3848 samples from the dataset showed that FT3 and FT4 levels differed between the increased and normal IOP groups. Increased expression of the <i>LOXL-AS1</i> gene was identified as a contributor to increased IOP, with <i>LOXL-AS1</i> expression increased in GO.</p><p><strong>Conclusion: </strong>Increased thyroid function is a risk factor for elevated IOP in patients with GO, with higher expression of <i>LOXL-AS1</i> in GO contributing to this effect.</p>\",\"PeriodicalId\":23765,\"journal\":{\"name\":\"Yonsei Medical Journal\",\"volume\":\"66 10\",\"pages\":\"675-684\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479196/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Yonsei Medical Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3349/ymj.2024.0468\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Yonsei Medical Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3349/ymj.2024.0468","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

摘要

目的:高眼压(High intraocular pressure, IOP)是Graves眼病(GO)的常见临床表现,但甲状腺功能改变眼压的机制尚不清楚。材料与方法:采用简单线性相关分析和Kruskal-Wallis检验确定眼压与氧化石墨烯临床表现的关系。采用多元线性回归分析评价与IOP变化显著相关的因素。IOP与甲状腺功能之间的关系通过国家健康和营养检查调查的数据进行验证,甲状腺功能与IOP之间的因果关系通过基于汇总数据的孟德尔随机化分析进行评估。通过对基因表达Omnibus数据集的分析,比较了氧化石墨烯患者和非氧化石墨烯患者的基因表达,并确定了相关的氧化石墨烯途径。结果:获得270例住院患者392例的临床资料,其中眼压增高142例,正常眼压250例。IOP与氧化石墨烯持续时间、临床活动评分(CAS)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)和促甲状腺素受体抗体的浓度呈线性相关。多元线性回归分析得出包含CAS、FT3浓度和性别的模型(r=0.46)。对数据集中3848个样本的分析表明,IOP升高组和正常IOP组之间FT3和FT4水平存在差异。LOXL-AS1基因的表达增加被认为是IOP升高的一个因素,在氧化石墨烯中LOXL-AS1表达增加。结论:甲状腺功能增高是氧化石墨烯患者IOP升高的危险因素,氧化石墨烯中LOXL-AS1的高表达与此有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Positive Relationships between Intraocular Pressure and Thyroid Function in Graves' Ophthalmopathy: A Three-Aspect Evidence Analysis.

Purpose: High intraocular pressure (IOP) is a frequent clinical manifestation of Graves' ophthalmopathy (GO), but little is known about the mechanism by which thyroid function alters IOP in GO.

Materials and methods: The relationships between IOP and clinical manifestations of GO were determined by simple linear correlation analysis and the Kruskal-Wallis test. Factors significantly associated with changes in IOP were evaluated by multiple linear regression analysis. The relationships between IOP and thyroid function were verified using data from the National Health and Nutrition Examination Survey, and causative relationships between thyroid function and IOP were assessed using summary-data-based Mendelian randomization analysis. Gene expression was compared in patients with and without GO using analysis of a Gene Expression Omnibus dataset, and associated GO pathways were identified.

Results: Clinical data were obtained from 392 hospitalizations of 270 patients, including 142 hospitalizations with increased IOP and 250 with normal IOP. IOP was linearly associated with GO duration, clinical activity score (CAS), and concentrations of free triiodothyronine (FT3), free thyroxine (FT4), and thyrotropin receptor antibodies. Multiple linear regression analysis yielded a model including CAS, FT3 concentration, and sex (r=0.46). Analysis of 3848 samples from the dataset showed that FT3 and FT4 levels differed between the increased and normal IOP groups. Increased expression of the LOXL-AS1 gene was identified as a contributor to increased IOP, with LOXL-AS1 expression increased in GO.

Conclusion: Increased thyroid function is a risk factor for elevated IOP in patients with GO, with higher expression of LOXL-AS1 in GO contributing to this effect.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Yonsei Medical Journal
Yonsei Medical Journal 医学-医学:内科
CiteScore
4.50
自引率
0.00%
发文量
167
审稿时长
3 months
期刊介绍: The goal of the Yonsei Medical Journal (YMJ) is to publish high quality manuscripts dedicated to clinical or basic research. Any authors affiliated with an accredited biomedical institution may submit manuscripts of original articles, review articles, case reports, brief communications, and letters to the Editor.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信