Dana E. Rollison , Melany A. Garcia , Rossybelle P. Amorrortu , Yayi Zhao , Brian Mittman , Kea Turner , Kedar Kirtane , Hatem Soliman , Margaret M. Byrne , Cathy Meade , Clement K. Gwede , Steven Eschrich , Jun Yin , Nathanael B. Stanley , Lindsay Fuzzell , Delilah Hernandez , Elliott-Tapia-Kwan , Susan T. Vadaparampil
{"title":"设计一个集群随机多级干预,以减少少数癌症患者转诊和入组癌症临床试验的障碍:ACT WONDER2S研究。","authors":"Dana E. Rollison , Melany A. Garcia , Rossybelle P. Amorrortu , Yayi Zhao , Brian Mittman , Kea Turner , Kedar Kirtane , Hatem Soliman , Margaret M. Byrne , Cathy Meade , Clement K. Gwede , Steven Eschrich , Jun Yin , Nathanael B. Stanley , Lindsay Fuzzell , Delilah Hernandez , Elliott-Tapia-Kwan , Susan T. Vadaparampil","doi":"10.1016/j.cct.2025.108096","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Non-Hispanic (NH) Black/African American (AA) and Hispanic cancer patients are underrepresented in cancer clinical trials (CCTs) due to patient, physician, and system-level barriers. Therefore, multi-level approaches are critical to address barriers to CCT participation. Presented here are the study design and baseline characteristics of ACT WONDER<sup>2</sup>S, a multi-level intervention (MLI) aimed to decrease barriers to NH Black/AA and Hispanic patient referral and enrollment in CCTs.</div></div><div><h3>Methods</h3><div>ACT WONDER<sup>2</sup>S is an MLI including community outreach and digital interventions for community and Moffitt Cancer Center (MCC) populations. Geospatial analytics were used to identify clusters of census tracts (“priority zones”) with high NH Black/AA and Hispanic populations for intervention deployment. Priority zones were then matched on population characteristics and randomized to receive the intervention (<em>n</em> = 7) or to serve as controls (n = 7). Baseline characteristics of the priority zones were described using US Census data and other public sources.</div></div><div><h3>Results</h3><div>Approximately 16.5 % and 35.8 % of the intervention priority zones are NH Black/AA or Hispanic, respectively. There are no statistically significant differences between groups in total population size (paired <em>t</em>-test <em>p</em>-value = 0.63), proportions of NH Black/AA (<em>p</em> = 0.13) and Hispanic populations (<em>p</em> = 0.17), or distance in miles from MCC (<em>p</em> = 0.64). The estimated number of cancer cases and CCT enrollment rates at baseline are also similar between groups.</div></div><div><h3>Conclusion</h3><div>If shown to be effective in increasing referral and enrollment of NH Black/AA and Hispanic cancer patients to CCTs, ACT WONDER<sup>2)</sup>S can be deployed across other geographic settings, thereby reducing disparities to CCT referral and enrollment on a national scale.</div></div>","PeriodicalId":10636,"journal":{"name":"Contemporary clinical trials","volume":"158 ","pages":"Article 108096"},"PeriodicalIF":1.9000,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Design of a cluster randomized multi-level intervention to decrease barriers to minority cancer patient referral and enrollment to cancer clinical trials: The ACT WONDER2S study\",\"authors\":\"Dana E. Rollison , Melany A. Garcia , Rossybelle P. Amorrortu , Yayi Zhao , Brian Mittman , Kea Turner , Kedar Kirtane , Hatem Soliman , Margaret M. Byrne , Cathy Meade , Clement K. Gwede , Steven Eschrich , Jun Yin , Nathanael B. Stanley , Lindsay Fuzzell , Delilah Hernandez , Elliott-Tapia-Kwan , Susan T. Vadaparampil\",\"doi\":\"10.1016/j.cct.2025.108096\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><div>Non-Hispanic (NH) Black/African American (AA) and Hispanic cancer patients are underrepresented in cancer clinical trials (CCTs) due to patient, physician, and system-level barriers. Therefore, multi-level approaches are critical to address barriers to CCT participation. Presented here are the study design and baseline characteristics of ACT WONDER<sup>2</sup>S, a multi-level intervention (MLI) aimed to decrease barriers to NH Black/AA and Hispanic patient referral and enrollment in CCTs.</div></div><div><h3>Methods</h3><div>ACT WONDER<sup>2</sup>S is an MLI including community outreach and digital interventions for community and Moffitt Cancer Center (MCC) populations. Geospatial analytics were used to identify clusters of census tracts (“priority zones”) with high NH Black/AA and Hispanic populations for intervention deployment. Priority zones were then matched on population characteristics and randomized to receive the intervention (<em>n</em> = 7) or to serve as controls (n = 7). Baseline characteristics of the priority zones were described using US Census data and other public sources.</div></div><div><h3>Results</h3><div>Approximately 16.5 % and 35.8 % of the intervention priority zones are NH Black/AA or Hispanic, respectively. There are no statistically significant differences between groups in total population size (paired <em>t</em>-test <em>p</em>-value = 0.63), proportions of NH Black/AA (<em>p</em> = 0.13) and Hispanic populations (<em>p</em> = 0.17), or distance in miles from MCC (<em>p</em> = 0.64). The estimated number of cancer cases and CCT enrollment rates at baseline are also similar between groups.</div></div><div><h3>Conclusion</h3><div>If shown to be effective in increasing referral and enrollment of NH Black/AA and Hispanic cancer patients to CCTs, ACT WONDER<sup>2)</sup>S can be deployed across other geographic settings, thereby reducing disparities to CCT referral and enrollment on a national scale.</div></div>\",\"PeriodicalId\":10636,\"journal\":{\"name\":\"Contemporary clinical trials\",\"volume\":\"158 \",\"pages\":\"Article 108096\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-09-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Contemporary clinical trials\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1551714425002903\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Contemporary clinical trials","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1551714425002903","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Design of a cluster randomized multi-level intervention to decrease barriers to minority cancer patient referral and enrollment to cancer clinical trials: The ACT WONDER2S study
Introduction
Non-Hispanic (NH) Black/African American (AA) and Hispanic cancer patients are underrepresented in cancer clinical trials (CCTs) due to patient, physician, and system-level barriers. Therefore, multi-level approaches are critical to address barriers to CCT participation. Presented here are the study design and baseline characteristics of ACT WONDER2S, a multi-level intervention (MLI) aimed to decrease barriers to NH Black/AA and Hispanic patient referral and enrollment in CCTs.
Methods
ACT WONDER2S is an MLI including community outreach and digital interventions for community and Moffitt Cancer Center (MCC) populations. Geospatial analytics were used to identify clusters of census tracts (“priority zones”) with high NH Black/AA and Hispanic populations for intervention deployment. Priority zones were then matched on population characteristics and randomized to receive the intervention (n = 7) or to serve as controls (n = 7). Baseline characteristics of the priority zones were described using US Census data and other public sources.
Results
Approximately 16.5 % and 35.8 % of the intervention priority zones are NH Black/AA or Hispanic, respectively. There are no statistically significant differences between groups in total population size (paired t-test p-value = 0.63), proportions of NH Black/AA (p = 0.13) and Hispanic populations (p = 0.17), or distance in miles from MCC (p = 0.64). The estimated number of cancer cases and CCT enrollment rates at baseline are also similar between groups.
Conclusion
If shown to be effective in increasing referral and enrollment of NH Black/AA and Hispanic cancer patients to CCTs, ACT WONDER2)S can be deployed across other geographic settings, thereby reducing disparities to CCT referral and enrollment on a national scale.
期刊介绍:
Contemporary Clinical Trials is an international peer reviewed journal that publishes manuscripts pertaining to all aspects of clinical trials, including, but not limited to, design, conduct, analysis, regulation and ethics. Manuscripts submitted should appeal to a readership drawn from disciplines including medicine, biostatistics, epidemiology, computer science, management science, behavioural science, pharmaceutical science, and bioethics. Full-length papers and short communications not exceeding 1,500 words, as well as systemic reviews of clinical trials and methodologies will be published. Perspectives/commentaries on current issues and the impact of clinical trials on the practice of medicine and health policy are also welcome.