{"title":"miRNA在糖尿病神经病变中的临床意义：病理生理学、诊断和治疗潜力。","authors":"Desh Deepak Singh","doi":"10.2174/0115733998375284250905115146","DOIUrl":null,"url":null,"abstract":"<p><p>Diabetic Neuropathy (DN) is the major chronic complication in diabetic patients. Exact pathophysiological mechanisms of DN are not explored well, although axon Schwann cell and microvascular endothelial communication network failure play a major contributing role in DN. The multiple pathophysiological mechanisms of DN are regulated by microRNAs (miRNAs), including inflammation, vascularization, angiogenesis, posttranscriptional regulation, intercellular communication, and signalling pathways. Various types of miRNA affect the gene expressions within cells, but their profiles often change during DN, including SMAD, PI3K, NF-KB, and MAPK. DN has been associated with the miRNAs-9, miRNA-106, miRNA-182, miRNA-23a, miRNA- 23b, miRNA-23c, miRNA-503, miRNA-203, miRNA-145, and miRNA-126. MiRNA dysregulation is one of the first molecular changes seen in diabetics. Therefore, miRNAs have potential as therapeutic targets and biomarkers. This study aims to discuss the importance of miRNA in clinical pathophysiology, diagnosis, signalling pathways, and therapeutic targets for DN.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinical Importance of miRNA in Diabetic Neuropathy: Pathophysiology, Diagnosis, and Therapeutic Potential.\",\"authors\":\"Desh Deepak Singh\",\"doi\":\"10.2174/0115733998375284250905115146\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Diabetic Neuropathy (DN) is the major chronic complication in diabetic patients. Exact pathophysiological mechanisms of DN are not explored well, although axon Schwann cell and microvascular endothelial communication network failure play a major contributing role in DN. The multiple pathophysiological mechanisms of DN are regulated by microRNAs (miRNAs), including inflammation, vascularization, angiogenesis, posttranscriptional regulation, intercellular communication, and signalling pathways. Various types of miRNA affect the gene expressions within cells, but their profiles often change during DN, including SMAD, PI3K, NF-KB, and MAPK. DN has been associated with the miRNAs-9, miRNA-106, miRNA-182, miRNA-23a, miRNA- 23b, miRNA-23c, miRNA-503, miRNA-203, miRNA-145, and miRNA-126. MiRNA dysregulation is one of the first molecular changes seen in diabetics. Therefore, miRNAs have potential as therapeutic targets and biomarkers. This study aims to discuss the importance of miRNA in clinical pathophysiology, diagnosis, signalling pathways, and therapeutic targets for DN.</p>\",\"PeriodicalId\":10825,\"journal\":{\"name\":\"Current diabetes reviews\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-09-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current diabetes reviews\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/0115733998375284250905115146\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current diabetes reviews","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0115733998375284250905115146","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Clinical Importance of miRNA in Diabetic Neuropathy: Pathophysiology, Diagnosis, and Therapeutic Potential.
Diabetic Neuropathy (DN) is the major chronic complication in diabetic patients. Exact pathophysiological mechanisms of DN are not explored well, although axon Schwann cell and microvascular endothelial communication network failure play a major contributing role in DN. The multiple pathophysiological mechanisms of DN are regulated by microRNAs (miRNAs), including inflammation, vascularization, angiogenesis, posttranscriptional regulation, intercellular communication, and signalling pathways. Various types of miRNA affect the gene expressions within cells, but their profiles often change during DN, including SMAD, PI3K, NF-KB, and MAPK. DN has been associated with the miRNAs-9, miRNA-106, miRNA-182, miRNA-23a, miRNA- 23b, miRNA-23c, miRNA-503, miRNA-203, miRNA-145, and miRNA-126. MiRNA dysregulation is one of the first molecular changes seen in diabetics. Therefore, miRNAs have potential as therapeutic targets and biomarkers. This study aims to discuss the importance of miRNA in clinical pathophysiology, diagnosis, signalling pathways, and therapeutic targets for DN.
期刊介绍：
Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
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