Enzo Shintaku, Davi Vantini, João Gabriel Bicudo Ting, Rubén David Dos Reis Zuniga, Glaucia Luciano da Veiga, Beatriz da Costa Aguiar Alves, Jéssica Freitas Encinas, Fernando Luiz Affonso Fonseca
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These studies used animal experiments, assessing irisin predominantly through Western blotting or ELISA, with aerobic exercise protocols, mainly treadmill running.</p><p><strong>Results: </strong>The results consistently showed an increase in irisin levels in response to physical exercise in animal models with kidney diseases.</p><p><strong>Discussion: </strong>Aerobic exercise increased plasma irisin expression, with better outcomes observed with low to medium-intensity training. Irisin demonstrated therapeutic potential by reducing renal cysts, inhibiting epithelial-mesenchymal transition, decreasing markers of diabetic nephropathy, and restoring autophagy in podocytes. Additionally, it activated the AMPK-Sirt1-PGC-1α pathway, suggesting antioxidant and antiapoptotic effects.</p><p><strong>Conclusion: </strong>The studies reviewed suggested that aerobic exercise increased irisin levels in animal models of kidney diseases, showing potential therapeutic effects for renal health.</p>","PeriodicalId":94316,"journal":{"name":"Endocrine, metabolic & immune disorders drug targets","volume":" ","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Assessment of Exercise-Stimulated Irisin in Kidney Disease: A Systematic Review.\",\"authors\":\"Enzo Shintaku, Davi Vantini, João Gabriel Bicudo Ting, Rubén David Dos Reis Zuniga, Glaucia Luciano da Veiga, Beatriz da Costa Aguiar Alves, Jéssica Freitas Encinas, Fernando Luiz Affonso Fonseca\",\"doi\":\"10.2174/0118715303381483250629164853\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Irisin is a hormone synthesized by skeletal muscle cells in response to physical exercise. 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引用次数: 0
摘要
鸢尾素是骨骼肌细胞在运动后合成的一种激素。它与各种健康益处有关，包括改善胰岛素敏感性，脂肪燃烧，减少炎症，以及对代谢疾病（如肥胖和2型糖尿病）的潜在保护。这篇综述探讨了体育锻炼刺激下鸢尾素在肾脏疾病中的作用。方法：采用SciELO、PubMed、Scopus、Web of Science、EMBASE进行综合评价。根据预先确定的资格标准选择了五篇文章。这些研究采用动物实验，主要通过免疫印迹法（Western blotting）或酶联免疫吸附试验（ELISA）评估鸢尾素，并辅以有氧运动方案，主要是跑步机。结果：结果一致表明，在肾脏疾病动物模型中，鸢尾素水平随着体育锻炼的增加而增加。讨论：有氧运动增加血浆鸢尾素表达，低至中等强度训练效果更好。鸢尾素通过减少肾囊肿、抑制上皮-间质转化、降低糖尿病肾病标志物和恢复足细胞自噬显示出治疗潜力。此外，它激活AMPK-Sirt1-PGC-1α通路，提示抗氧化和抗凋亡作用。结论：有氧运动可提高肾脏疾病动物模型中的鸢尾素水平，对肾脏健康具有潜在的治疗作用。
Assessment of Exercise-Stimulated Irisin in Kidney Disease: A Systematic Review.
Introduction: Irisin is a hormone synthesized by skeletal muscle cells in response to physical exercise. It has been linked to various health benefits, including improved insulin sensitivity, fat burning, reduced inflammation, and potential protection against metabolic diseases, such as obesity and type 2 diabetes. This review explores the role of irisin, stimulated by physical exercise, in kidney diseases.
Methods: A comprehensive review was conducted using SciELO, PubMed, Scopus, Web of Science, and EMBASE. Five articles were selected based on pre-established eligibility criteria. These studies used animal experiments, assessing irisin predominantly through Western blotting or ELISA, with aerobic exercise protocols, mainly treadmill running.
Results: The results consistently showed an increase in irisin levels in response to physical exercise in animal models with kidney diseases.
Discussion: Aerobic exercise increased plasma irisin expression, with better outcomes observed with low to medium-intensity training. Irisin demonstrated therapeutic potential by reducing renal cysts, inhibiting epithelial-mesenchymal transition, decreasing markers of diabetic nephropathy, and restoring autophagy in podocytes. Additionally, it activated the AMPK-Sirt1-PGC-1α pathway, suggesting antioxidant and antiapoptotic effects.
Conclusion: The studies reviewed suggested that aerobic exercise increased irisin levels in animal models of kidney diseases, showing potential therapeutic effects for renal health.
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