基于抗体的治疗制剂开发的机会。

IF 4.5 Q2 Medicine

Antibody Therapeutics Pub Date : 2025-08-22 eCollection Date: 2025-07-01 DOI:10.1093/abt/tbaf016

Qingyan Hu, Yunsong Frank Li

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引用次数: 0

摘要

制剂将活性药物成分转化为制剂，确保稳定性、可制造性、有效性和患者安全性。在生物技术进步和患者需求的推动下，新的基于抗体的疗法和组合正在扩大，显着改变了配方景观。这篇社论概述了基于抗体的治疗制剂的配方，并强调了一些热点话题和新兴趋势，包括高浓度配方、固定剂量组合、新型赋形剂和给药技术以及人工智能集成。随着该领域的发展，创新技术和可持续实践将在解决对基于抗体的疗法日益增长的需求方面发挥重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Opportunities in formulation development of antibody-based therapeutics.

Drug product formulation transforms active pharmaceutical ingredients into drug products, ensuring stability, manufacturability, efficacy, and patient safety. Driven by biotech advancements and patient needs, new antibody-based therapies and combinations are expanding, significantly evolving the formulation landscape. This editorial provides an overview of formulations for antibody-based therapeutics and highlights a few hot topics and emerging trends, including high concentration formulations, fixed-dose combinations, novel excipients and delivery technologies, and AI integration. As the field progresses, innovative technologies and sustainable practices will be important in addressing the increasing demand for antibody-based therapies.

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来源期刊

Antibody Therapeutics Medicine-Immunology and Allergy

CiteScore

8.70

自引率

0.00%

发文量

审稿时长

8 weeks