循环鞘脂与CKD:强心脏家族研究。

IF 3 Q1 UROLOGY & NEPHROLOGY
Kidney360 Pub Date : 2025-09-24 DOI:10.34067/KID.0000000960
Amanda M Fretts, Paul N Jensen, Benjamin Lidgard, Colleen M Sitlani, David S Siscovick, Irena B King, Reya H Mokiao, Andrew N Hoofnagle, Jason G Umans, Rozenn N Lemaitre
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引用次数: 0

摘要

背景:在基于社区的研究中,很少有研究评估神经酰胺和鞘磷脂种类是否与肾脏健康相关。我们研究了8种神经酰胺和鞘磷脂与CKD发生的关系(eGFR)方法:我们纳入了来自强心脏家族研究的参与者,这是一项关于心脏代谢疾病危险因素的前瞻性队列研究。我们使用广义估计方程来检验神经酰胺(Cer)-16、Cer-20、Cer-22、Cer-24、鞘磷脂(SM-16)、SM-20、SM-22和SM-24与肾脏健康的关系。结果:共有95名参与者在基线时患有CKD, 79名参与者在平均5.4年的随访期间患上了CKD, 2167名参与者仍然没有CKD, 270名参与者的eGFR快速下降,每1.73 m2每年下降bb0.3 mL/min。多变量调整后,较高水平的SM-16与CKD风险增加相关(RR=1.69, 95% CI: 1.24-2.23),而较高水平的SM-24与肾功能快速下降的风险降低相关(RR, 95% CI: 0.71, 0.58-0.87)。较高水平的循环SM-24也与较高的eGFR相关(RR=1.33, 95% CI, 0.47, 2.18)。Cer-16、Cer-20、Cer-22、Cer-24和SM-20与肾脏健康无关。结论:神经酰胺和鞘磷脂与肾脏健康的关系取决于附着在鞘磷脂上的酰基化饱和脂肪酸的长度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Circulating Sphingolipids and Incident CKD: The Strong Heart Family Study.

Background: Few studies have assessed whether ceramides and sphingomyelin species are associated with kidney health in community-based studies. We investigated associations of 8 ceramide and sphingomyelin species with incident CKD (eGFR <60 mL/min/1.73 m2) and other markers of kidney health (i.e., rapid decline in kidney function, estimated glomerular filtration rate (eGFR), urine albumin-to-creatinine ratio) in a large cohort of American Indians.

Methods: We included participants from the Strong Heart Family Study, a prospective cohort study of risk factors for cardio-metabolic diseases. We used generalized estimating equations to examine associations of ceramide (Cer)-16, Cer-20, Cer-22, Cer-24, sphingomyelin (SM-16), SM-20, SM-22, and SM-24, with kidney health.

Results: In total, 95 participants had CKD at baseline, 79 participants developed CKD during a mean follow up of 5.4 years, 2,167 participants remained free of CKD, and 270 participants experienced rapid decline in eGFR of >3 mL/min per 1.73 m2 per year. After multivariable adjustment, higher levels of SM-16 were associated with greater risk of CKD (RR=1.69, 95% CI: 1.24-2.23), while higher levels of SM-24 were associated with lower risk of rapid decline in kidney function (RR, 95% CI: 0.71, 0.58-0.87). Higher levels of circulating SM-24 were also associated with higher eGFR (RR=1.33, 95% CI, 0.47, 2.18). Cer-16, Cer-20, Cer-22, Cer-24, and SM-20 were not associated with kidney health.

Conclusions: Associations of ceramide and sphingomyelins with kidney health differ based on the length of the acylated saturated fatty acid attached to the sphingomyelin.

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来源期刊
Kidney360
Kidney360 UROLOGY & NEPHROLOGY-
CiteScore
3.90
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