福洛匹坦/帕洛诺司琼：首次批准。

IF 14.4 1区医学 Q1 PHARMACOLOGY & PHARMACY

Drugs Pub Date : 2025-09-24 DOI:10.1007/s40265-025-02225-6

Simon Fung

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引用次数: 0

摘要

Fosrolapitant/palonosetron （Ritanine®；®）是一种固定剂量的组合，Fosrolapitant是一种新型神经动素-1 （NK-1）受体拮抗剂前药，palonosetron是第二代5-羟色胺-3 （5-HT3）受体拮抗剂。它是由福建盛迪制药开发的，用于预防化疗引起的恶心和呕吐。2025年5月29日，fosolapitan /palonosetron在中国首次获得批准，用于预防成人高致吐性化疗引起的急性和延迟性恶心和呕吐。这篇文章总结了fosolapitan /palonosetron在化疗引起的恶心和呕吐中首次被批准的发展里程碑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Fosrolapitant/Palonosetron: First Approval.

Fosrolapitant/palonosetron (Ritanine^®; ^®) is a fixed-dose combination of fosrolapitant, a novel neurokinin-1 (NK-1) receptor antagonist prodrug, and palonosetron, a second generation 5-hydroxytryptamine-3 (5-HT3) receptor antagonist. It is being developed by Fujian Shengdi Pharmaceutical as a preventative treatment of chemotherapy-induced nausea and vomiting. On the 29^th of May 2025, fosrolapitant/palonosetron received its first approval in China for the prevention of acute and delayed nausea and vomiting caused by highly emetogenic chemotherapy in adults. This article summarizes the milestones in the development of fosrolapitant/palonosetron leading to this first approval in chemotherapy-induced nausea and vomiting.

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来源期刊

Drugs 医学-毒理学

CiteScore

22.70

自引率

0.90%

发文量

134

审稿时长

3-8 weeks

期刊介绍： Drugs is a journal that aims to enhance pharmacotherapy by publishing review and original research articles on key aspects of clinical pharmacology and therapeutics. The journal includes: Leading/current opinion articles providing an overview of contentious or emerging issues. Definitive reviews of drugs and drug classes, and their place in disease management. Therapy in Practice articles including recommendations for specific clinical situations. High-quality, well designed, original clinical research. Adis Drug Evaluations reviewing the properties and place in therapy of both newer and established drugs. AdisInsight Reports summarising development at first global approval. Moreover, the journal offers additional digital features such as animated abstracts, video abstracts, instructional videos, and podcasts to increase visibility and educational value. Plain language summaries accompany articles to assist readers with some knowledge of the field in understanding important medical advances.