血浆β-内啡肽和神经肽Y作为预测阻塞性睡眠呼吸暂停综合征的候选生物标志物:初步研究

IF 2.1 4区 医学 Q3 RESPIRATORY SYSTEM
Canadian respiratory journal Pub Date : 2025-09-15 eCollection Date: 2025-01-01 DOI:10.1155/carj/4316574
Meng-Lin Li, Yi Yang, Qian-Yun Huang, Jian-Yong Liu
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引用次数: 0

摘要

背景与目的:考虑到神经肽参与阻塞性睡眠呼吸暂停综合征(OSAS)的病理生理过程,本研究探讨了血浆β-内啡肽(β-EP)和神经肽Y (NPY)水平与OSAS严重程度之间的关系,并评估其作为预测性生物标志物的潜力。方法:采用多导睡眠图(PSG)将48例鼾症患者按呼吸暂停低通气指数(AHI)分为非OSAS组、轻度、中度和重度OSAS组(每组12例)。ELISA法测定血浆β-EP和NPY水平。统计分析包括单因素方差分析、Spearman相关分析和受试者工作特征(ROC)曲线分析来评估预测效果。结果:与非OSAS组相比,中度OSAS组(p=0.003)和重度OSAS组(p=0.032)血浆β-EP水平显著升高。值得注意的是,NPY水平在所有OSAS严重程度组之间存在显著差异(p < 0.01),轻度、中度和重度OSAS患者的浓度明显高于非OSAS对照组(p < 0.01)。随着OSAS严重程度的加重,NPY水平逐渐升高,组间差异有统计学意义(p < 0.01)。相关分析显示,NPY水平与BMI (p < 0.0001)和AHI (p < 0.0001)呈正相关。β-EP与AHI呈正相关(p < 0.0001),与BMI无显著相关性(p=0.0931)。ROC曲线分析发现β-EP(截止值:9.405 ng/L)是osaas的中度预测因子(AUC = 0.7986, p < 0.01;敏感性:72.22%,特异性:83.33%)。值得注意的是,NPY(截止值:19.29 ng/L)表现出完美的鉴别能力(AUC = 1, p < 0.0001;灵敏度:97.22%,特异性:100%)。结论:血浆β-EP和NPY水平与OSAS严重程度相关,可能作为潜在的生物标志物。然而,需要在更大的队列中进一步验证以确认其临床应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Plasma β-Endorphin and Neuropeptide Y as Candidate Biomarkers for Predicting Obstructive Sleep Apnea Syndrome: A Preliminary Study.

Background and Objective: Given the involvement of neuropeptides in the pathophysiology of obstructive sleep apnea syndrome (OSAS), this study investigated the associations between plasma levels of β-endorphin (β-EP) and neuropeptide Y (NPY) and OSAS severity and evaluated their potential as predictive biomarkers. Methods: A total of 48 snoring patients undergoing polysomnography (PSG) were categorized into non-OSAS, mild, moderate, and severe OSAS groups (n = 12 per group) based on the apnea-hypopnea index (AHI). Plasma levels of β-EP and NPY were measured using ELISA. Statistical analyses included one-way ANOVA, Spearman's correlation, and receiver operating characteristic (ROC) curve analysis to assess predictive performance. Results: Plasma β-EP levels exhibited significant elevation in moderate (p=0.003) and severe OSAS groups (p=0.032) compared to the non-OSAS group. Notably, NPY levels demonstrated marked differences across all OSAS severity groups (p < 0.01), with significantly higher concentrations observed in mild, moderate, and severe OSAS patients versus non-OSAS controls (p < 0.01). A progressive increase in NPY levels was observed with advancing OSAS severity, accompanied by statistically significant intergroup differences (p < 0.01). Correlation analyses revealed strong positive associations between NPY levels and both BMI (p < 0.0001) and AHI (p < 0.0001). In contrast, β-EP correlated positively with AHI (p < 0.0001) but not with BMI (p=0.0931). ROC curve analysis identified β-EP (cutoff: 9.405 ng/L) as a moderate predictor of OSAS (AUC = 0.7986, p < 0.01; sensitivity: 72.22%, specificity: 83.33%). Strikingly, NPY (cutoff: 19.29 ng/L) exhibited perfect discriminative capacity (AUC = 1, p < 0.0001; sensitivity: 97.22%, specificity: 100%). Conclusions: Plasma β-EP and NPY levels are associated with OSAS severity and may serve as potential biomarkers. However, further validation in larger cohorts is needed to confirm their clinical utility.

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来源期刊
Canadian respiratory journal
Canadian respiratory journal 医学-呼吸系统
CiteScore
4.20
自引率
0.00%
发文量
61
审稿时长
6-12 weeks
期刊介绍: Canadian Respiratory Journal is a peer-reviewed, Open Access journal that aims to provide a multidisciplinary forum for research in all areas of respiratory medicine. The journal publishes original research articles, review articles, and clinical studies related to asthma, allergy, COPD, non-invasive ventilation, therapeutic intervention, lung cancer, airway and lung infections, as well as any other respiratory diseases.
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