High-Risk HPV-Positive Sinonasal Adenocarcinoma: A Case Report and Review of Literature.

High risk human papillomavirus (HR-HPV) has been a well-documented etiology of oropharyngeal malignancy. Recently, the sinonasal tract has been recognized as a second "hot spot" in the head and neck region for HPV associated tumors. Most HR-HPV associated tumors in the sinonasal tract are squamous cell carcinomas. High-grade non-intestinal type sinonasal adenocarcinoma (NITAC) is a rare malignant neoplasm that, to our knowledge, has been convincingly reported just once previously in association with HR-HPV. We report a new case of high grade NITAC associated with HR-HPV in a 64-year-old male patient, along with a literature review emphasizing differential diagnoses and potential clinical implications.