{"title":"新包装，旧成分：RHEIA试验真正告诉我们关于女性TAVI的什么？","authors":"Pradeep Narayan","doi":"10.1007/s12055-025-02067-7","DOIUrl":null,"url":null,"abstract":"<p><p>The Randomized researcH in womEn all comers wIth Aortic stenosis (RHEIA) trial is the first randomized study to compare transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) exclusively in low-risk women with severe aortic stenosis. While results showed statistical superiority of TAVI for the composite endpoint of death, stroke, or rehospitalization at 1 year, this was driven primarily by reduced readmission rates. Mortality and stroke outcomes were similar between groups. Significant procedural imbalances and reliance on as-treated analysis raise concerns about interpretation. RHEIA not only fills a critical evidence gap in sex-specific valve therapy but also highlights persistent methodological challenges in evaluating treatment efficacy in this population.</p>","PeriodicalId":13285,"journal":{"name":"Indian Journal of Thoracic and Cardiovascular Surgery","volume":"41 10","pages":"1513-1515"},"PeriodicalIF":0.6000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12450130/pdf/","citationCount":"0","resultStr":"{\"title\":\"New packaging, old ingredients: what the RHEIA Trial really tells us about TAVI in women?\",\"authors\":\"Pradeep Narayan\",\"doi\":\"10.1007/s12055-025-02067-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The Randomized researcH in womEn all comers wIth Aortic stenosis (RHEIA) trial is the first randomized study to compare transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) exclusively in low-risk women with severe aortic stenosis. While results showed statistical superiority of TAVI for the composite endpoint of death, stroke, or rehospitalization at 1 year, this was driven primarily by reduced readmission rates. Mortality and stroke outcomes were similar between groups. Significant procedural imbalances and reliance on as-treated analysis raise concerns about interpretation. RHEIA not only fills a critical evidence gap in sex-specific valve therapy but also highlights persistent methodological challenges in evaluating treatment efficacy in this population.</p>\",\"PeriodicalId\":13285,\"journal\":{\"name\":\"Indian Journal of Thoracic and Cardiovascular Surgery\",\"volume\":\"41 10\",\"pages\":\"1513-1515\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12450130/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian Journal of Thoracic and Cardiovascular Surgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s12055-025-02067-7\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/21 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Thoracic and Cardiovascular Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12055-025-02067-7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/21 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
New packaging, old ingredients: what the RHEIA Trial really tells us about TAVI in women?
The Randomized researcH in womEn all comers wIth Aortic stenosis (RHEIA) trial is the first randomized study to compare transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) exclusively in low-risk women with severe aortic stenosis. While results showed statistical superiority of TAVI for the composite endpoint of death, stroke, or rehospitalization at 1 year, this was driven primarily by reduced readmission rates. Mortality and stroke outcomes were similar between groups. Significant procedural imbalances and reliance on as-treated analysis raise concerns about interpretation. RHEIA not only fills a critical evidence gap in sex-specific valve therapy but also highlights persistent methodological challenges in evaluating treatment efficacy in this population.
期刊介绍：
The primary aim of the Indian Journal of Thoracic and Cardiovascular Surgery is education. The journal aims to dissipate current clinical practices and developments in the area of cardiovascular and thoracic surgery. This includes information on cardiovascular epidemiology, aetiopathogenesis, clinical manifestation etc. The journal accepts manuscripts from cardiovascular anaesthesia, cardiothoracic and vascular nursing and technology development and new/innovative products.The journal is the official publication of the Indian Association of Cardiovascular and Thoracic Surgeons which has a membership of over 1000 at present.DescriptionThe journal is the official organ of the Indian Association of Cardiovascular-Thoracic Surgeons. It was started in 1982 by Dr. Solomon Victor and ws being published twice a year up to 1996. From 2000 the editorial office moved to Delhi. From 2001 the journal was extended to quarterly and subsequently four issues annually have been printed out at time and regularly without fail. The journal receives manuscripts from members and non-members and cardiovascular surgeons. The manuscripts are peer reviewed by at least two or sometimes three or four reviewers who are on the panel. The manuscript process is now completely online. Funding the journal comes partially from the organization and from revenue generated by subscription and advertisement.
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