老年人他汀类药物相关肌肉症状

IF 3 3区医学 Q2 PHARMACOLOGY & PHARMACY

Expert Review of Clinical Pharmacology Pub Date : 2025-09-22 DOI:10.1080/17512433.2025.2565619

Elizabeth K Pogge, Nicole K Early

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引用次数: 0

摘要

他汀类药物被强烈推荐用于减少主要的不良心血管事件，使其成为卫生保健提供者广泛开的处方。尽管如此，他汀类药物在老年人（≥65岁）中的利用不足，部分原因与担心不良反应有关。他汀类药物相关肌肉症状（SAMS）通常被认为是他汀类药物停药的原因。涵盖领域：本综述讨论了老年人SAMS的发病率、影响因素和临床试验数据。提出了一种治疗老年SAMS的方法。专家意见：治疗经历SAMS的老年人是具有挑战性的。利用共同决策，经历SAMS的患者可能会成功地再次使用他汀类药物。如果患者不能耐受他汀类药物，可以考虑使用非他汀类药物治疗以降低胆固醇并改善心血管预后。

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Statin associated muscle symptoms in older adults.

Introduction: Statins are strongly recommended to reduce major adverse cardiovascular events, making them widely prescribed by health-care providers. Despite this, statins are underutilized in older adults (≥65 years of age), partially related to the fear of adverse effects. Statin associated muscle symptoms (SAMS) are commonly cited as a reason for statin discontinuation.

Areas covered: This review discusses the incidence, contributing factors, and clinical trial data surrounding SAMS in older adults. An approach to treating older adults with SAMS is proposed.

Expert opinion: Treating older adults who experience SAMS is challenging. Utilizing shared decision-making, patients who experience SAMS may be successfully rechallenged with a statin. If a patient is unable to tolerate a statin, non-statin therapeutic options can be considered to reduce cholesterol and improve cardiovascular outcomes.

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来源期刊

Expert Review of Clinical Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

7.30

自引率

2.30%

发文量

127

期刊介绍： Advances in drug development technologies are yielding innovative new therapies, from potentially lifesaving medicines to lifestyle products. In recent years, however, the cost of developing new drugs has soared, and concerns over drug resistance and pharmacoeconomics have come to the fore. Adverse reactions experienced at the clinical trial level serve as a constant reminder of the importance of rigorous safety and toxicity testing. Furthermore the advent of pharmacogenomics and ‘individualized’ approaches to therapy will demand a fresh approach to drug evaluation and healthcare delivery. Clinical Pharmacology provides an essential role in integrating the expertise of all of the specialists and players who are active in meeting such challenges in modern biomedical practice.