立体细胞：推进空间单细胞生物学走向临床翻译。

IF 6.8 1区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Clinical and Translational Medicine Pub Date : 2025-09-23 DOI:10.1002/ctm2.70480

Christian Baumgartner

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引用次数: 0

摘要

立体细胞是一个新开发的空间单细胞测序平台，整合了形态学，转录组学和蛋白质组学在高分辨率。通过保留空间背景，同时实现多模态分析，它弥合了先进组学和传统病理学之间的差距，支持稀有细胞的检测和临床可解释的诊断。这封信强调了Stereo-cell的技术创新，它在空间组学领域的定位，以及它在精准医疗方面的潜力。数据集成、法规遵从和数字建模方面的重要挑战是临床实施道路上的重要步骤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Stereo-cell: Advancing spatial single-cell biology towards clinical translation

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Stereo-cell: Advancing spatial single-cell biology towards clinical translation

Stereo-cell is a newly developed platform for spatial single-cell sequencing that integrates morphology, transcriptomics, and proteomics in high resolution. By preserving spatial context while enabling multimodal profiling, it bridges the gap between advanced omics and traditional pathology, supporting the detection of rare cells and clinically interpretable diagnoses. This letter highlights the technical innovations of Stereo-cell, its positioning within the spatial omics landscape, and its potential for precision medicine. Important challenges in data integration, regulatory compliance, and digital modelling are discussed as essential steps on the path to clinical implementation.

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来源期刊

Clinical and Translational Medicine Multiple-

CiteScore

15.90

自引率

1.90%

发文量

450

审稿时长

4 weeks

期刊介绍： Clinical and Translational Medicine (CTM) is an international, peer-reviewed, open-access journal dedicated to accelerating the translation of preclinical research into clinical applications and fostering communication between basic and clinical scientists. It highlights the clinical potential and application of various fields including biotechnologies, biomaterials, bioengineering, biomarkers, molecular medicine, omics science, bioinformatics, immunology, molecular imaging, drug discovery, regulation, and health policy. With a focus on the bench-to-bedside approach, CTM prioritizes studies and clinical observations that generate hypotheses relevant to patients and diseases, guiding investigations in cellular and molecular medicine. The journal encourages submissions from clinicians, researchers, policymakers, and industry professionals.