肥胖与耐力运动训练:血浆三酰甘油和肌肉脂蛋白脂肪酶活性在肌肉脂质积累的十字路口。

IF 3.1 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Kailin Johnsson, Jessica G George, Elizabeth J Parks, Christos S Katsanos
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引用次数: 0

摘要

与健康、久坐不动的人相比,肥胖和耐力训练的运动员骨骼肌中的脂质含量都过高,但他们的健康结果却截然不同。在这两种人群中,从循环中吸收的脂质有助于在肌肉中储存脂质。在肥胖和耐力训练的运动员之间,肌肉摄取血浆非酯化脂肪酸(NEFA)和血浆三酰甘油(TG)脂肪酸的差异尚未得到系统的研究。在运动员中,肌肉通过上调肌肉脂蛋白脂肪酶(负责血管内TG水解的酶)的活性来主动调节TG衍生脂肪酸的摄取,这一现象在禁食状态下很明显。相反,在肥胖个体中,骨骼肌作为TG衍生脂肪酸的被动受体,当餐后血浆TG浓度升高时,这一事件在数量上变得更加重要。在运动员和肥胖个体之间,血浆NEFA的肌肉摄取的显著差异不太明显。这些观察结果表明,肥胖个体和耐力训练运动员在肌肉中形成过量脂质含量时,血浆tg源性脂肪酸摄取的调节机制存在差异。此外,这一证据强调了在肥胖的病理生理中,当旨在减轻肌肉中的脂质积累时,需要在餐后状态下靶向血浆TG的降低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Obesity versus Endurance Exercise Training: Plasma Triacylglycerol and Muscle Lipoprotein Lipase Activity at the Crossroads of Lipid Accumulation in Muscle.

Individuals with obesity and endurance exercise-trained athletes both exhibit excess lipid content in their skeletal muscle compared to healthy, sedentary individuals, yet they experience vastly different health outcomes. Lipids taken up from the circulation contribute to lipid stored in muscle in both populations. Differences in the muscle uptake of plasma non-esterified fatty acids (NEFA) and fatty acids derived from plasma triacylglycerol (TG) between individuals with obesity and endurance-trained athletes have not been systematically examined. In athletes, muscle actively regulates the uptake of TG-derived fatty acids through upregulation of the activity of muscle lipoprotein lipase - the enzyme responsible for the intravascular hydrolysis of TG, a phenomenon evident in the fasting state. In contrast, in individuals with obesity, skeletal muscle functions as a passive recipient of TG-derived fatty acids, an event that becomes quantitively more important when the plasma TG concentrations increase during the postprandial state. Considerable differences in the muscle uptake of plasma NEFA between athletes and individuals with obesity are less evident. These observations indicate mechanistic differences in the regulation of plasma TG-derived fatty acids uptake in muscle between individuals with obesity and endurance-trained athletes in shaping the excess lipid content in their muscles. Moreover, this evidence highlights the need for targeting a reduction in plasma TG in the postprandial state when aiming to attenuate lipid accumulation in muscle in the pathophysiology of obesity.

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来源期刊
CiteScore
9.80
自引率
0.00%
发文量
98
审稿时长
1 months
期刊介绍: The American Journal of Physiology-Endocrinology and Metabolism publishes original, mechanistic studies on the physiology of endocrine and metabolic systems. Physiological, cellular, and molecular studies in whole animals or humans will be considered. Specific themes include, but are not limited to, mechanisms of hormone and growth factor action; hormonal and nutritional regulation of metabolism, inflammation, microbiome and energy balance; integrative organ cross talk; paracrine and autocrine control of endocrine cells; function and activation of hormone receptors; endocrine or metabolic control of channels, transporters, and membrane function; temporal analysis of hormone secretion and metabolism; and mathematical/kinetic modeling of metabolism. Novel molecular, immunological, or biophysical studies of hormone action are also welcome.
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