{"title":"细胞的主要划分原则:胞浆组装、相分离和膜包合","authors":"Ji-Long Liu","doi":"10.1016/j.yexcr.2025.114766","DOIUrl":null,"url":null,"abstract":"<div><div>In the 4.6 billion year history, the Earth we live on has nurtured a diverse range of life forms. The basic unit of life is the cell. Since the discovery of cells 360 years ago, scientists have gained a deep understanding of their structure, function, and heterogeneity. In order to understand the mechanisms and laws of cell structure, here I propose three primary partitioning principles of the cell, namely cytoophidium assembly, phase separation, and membrane enclosure. From the perspective of partitioning principles, I introduce these three principles separately and then compare them. Furthermore, I attempt to elucidate the primary partitioning principles from the perspectives of mathematics, physics, chemistry, evolution, and communications.</div></div>","PeriodicalId":12227,"journal":{"name":"Experimental cell research","volume":"452 2","pages":"Article 114766"},"PeriodicalIF":3.5000,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Primary partitioning principles of the cell: Cytoophidium assembly, phase separation and membrane enclosure\",\"authors\":\"Ji-Long Liu\",\"doi\":\"10.1016/j.yexcr.2025.114766\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>In the 4.6 billion year history, the Earth we live on has nurtured a diverse range of life forms. The basic unit of life is the cell. Since the discovery of cells 360 years ago, scientists have gained a deep understanding of their structure, function, and heterogeneity. In order to understand the mechanisms and laws of cell structure, here I propose three primary partitioning principles of the cell, namely cytoophidium assembly, phase separation, and membrane enclosure. From the perspective of partitioning principles, I introduce these three principles separately and then compare them. Furthermore, I attempt to elucidate the primary partitioning principles from the perspectives of mathematics, physics, chemistry, evolution, and communications.</div></div>\",\"PeriodicalId\":12227,\"journal\":{\"name\":\"Experimental cell research\",\"volume\":\"452 2\",\"pages\":\"Article 114766\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-09-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Experimental cell research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0014482725003660\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental cell research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0014482725003660","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Primary partitioning principles of the cell: Cytoophidium assembly, phase separation and membrane enclosure
In the 4.6 billion year history, the Earth we live on has nurtured a diverse range of life forms. The basic unit of life is the cell. Since the discovery of cells 360 years ago, scientists have gained a deep understanding of their structure, function, and heterogeneity. In order to understand the mechanisms and laws of cell structure, here I propose three primary partitioning principles of the cell, namely cytoophidium assembly, phase separation, and membrane enclosure. From the perspective of partitioning principles, I introduce these three principles separately and then compare them. Furthermore, I attempt to elucidate the primary partitioning principles from the perspectives of mathematics, physics, chemistry, evolution, and communications.
期刊介绍:
Our scope includes but is not limited to areas such as: Chromosome biology; Chromatin and epigenetics; DNA repair; Gene regulation; Nuclear import-export; RNA processing; Non-coding RNAs; Organelle biology; The cytoskeleton; Intracellular trafficking; Cell-cell and cell-matrix interactions; Cell motility and migration; Cell proliferation; Cellular differentiation; Signal transduction; Programmed cell death.