乳腺密度对早期乳腺癌射频消融疗效的影响。

IF 2.9
Manabu Futamura, Yasuko Nagao, Yukiko Takai, Yoshimi Niwa, Akira Nakakami, Mai Okawa, Yoshihisa Tokumaru, Junichi Mase, Ryutaro Mori, Daichi Watanabe, Takayuki Kinoshita, Nobuhisa Matsuhashi
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引用次数: 0

摘要

背景:射频消融(RFA)是一种用于治疗乳腺小肿瘤的微创技术。射频消融包括在超声引导下通过针电极输送高频电流。在日本,自2023年以来,RFA作为早期乳腺癌的局部治疗选择,已被纳入保险范围。方法:回顾性分析2016年2月至2025年3月在我院接受RFA治疗的患者资料。根据乳腺成像报告和数据系统将乳腺密度分为四类。评估乳腺密度与射频消融参数(包括消融温度、时间和阻抗)之间的关系。结果:49例女性患者共50个乳房接受RFA治疗。冷却中断后的平均峰值烧蚀温度为81.0±8.0℃。乳房密度增加与高温显著相关。消融至破裂的平均时间为446±139秒,表明在乳腺组织致密的病例中,消融时间有延长的趋势。平均初始和最终阻抗值分别为208±72.3 Ω和161±66.5 Ω。富含脂肪的乳房在两个时间点都表现出明显更高的阻抗值。结论:脂肪性乳腺组织与较高的阻抗、较低的峰值温度和较短的消融时间相关,可能导致消融不足。在计划射频消融时应考虑乳腺密度,以确保最佳治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of breast density on the efficacy of radiofrequency ablation in early-stage breast cancer.

Background: Radiofrequency ablation (RFA) is a minimally invasive technique employed in the management of small breast tumors. RFA involves the delivery of a high-frequency current through a needle electrode under ultrasound guidance. In Japan, RFA has been covered by insurance since 2023 as a localized treatment option for early-stage breast cancers.

Methods: We retrospectively analyzed the data of patients who underwent RFA at our institution between February 2016 and March 2025. Breast density was classified into four categories based on the Breast Imaging Reporting and Data System. Associations between breast density and RFA parameters, including ablation temperature, time, and impedance, were evaluated.

Results: A total of 50 breasts in 49 female patients were treated with RFA. The mean peak ablation temperature recorded after the cooling break was 81.0 ± 8.0 °C. Increased breast density was significantly associated with high temperatures. The mean ablation time until break was 446 ± 139 s, indicating a trend toward prolonged durations in cases involving denser breast tissue. The mean initial and final impedance values were 208 ± 72.3 Ω and 161 ± 66.5 Ω, respectively. Fat-rich breasts exhibited significantly higher impedance values at both time points.

Conclusion: Fatty breast tissue is associated with higher impedance, lower peak temperatures, and shorter ablation times, potentially resulting in insufficient ablation. Breast density should be considered when planning RFA to ensure optimal treatment efficacy.

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