BRAF V600E液体活检在精准肿瘤学检测中的应用。

IF 1.1 Q4 MEDICAL LABORATORY TECHNOLOGY
Advances in laboratory medicine Pub Date : 2025-08-15 eCollection Date: 2025-09-01 DOI:10.1515/almed-2025-0110
Gabriela R Mendeluk, Verónica A Alonso
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引用次数: 0

摘要

BRAF V600E突变是精准肿瘤学中最相关的基因突变之一。这种变异通常存在于几种类型的肿瘤中,包括黑色素瘤、结直肠癌和甲状腺癌等。液体活检已经成为这种突变的一种微创筛查选择。内容:本文综述了BRAF V600E突变的分子生物学、在肿瘤进展中的作用以及在特定类型肿瘤的诊断、预后和治疗中的应用。此外,重点还放在基于液体活检的筛查选择及其相对于固体活检的优势上。摘要:通过液体活检检测这种突变提供了一种比传统组织活检侵入性更小的选择,在指导治疗调整和监测治疗反应方面具有潜在的效用。展望:液体活检检测BRAF V600E有望广泛应用于临床实践,从而优化癌症患者的疾病监测和个性化治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
BRAF V600E liquid biopsy-based detection in precision oncology.

Introduction: The BRAF V600E mutation is one of the most relevant genetic mutations in precision oncology. This variation is commonly found in several types of tumors, including melanoma, colorectal cancer, and thyroid cancer, to name a few. Liquid biopsy has emerged as a minimally-invasive screening option for this mutation.

Content: This review examines the molecular biology of the BRAF V600E mutation, its role in tumor progression, and its utility in the diagnosis, prognosis and treatment of specific types of tumors. In addition, the focus is also placed on liquid biopsy-based screening options and their advantages over solid biopsy.

Summary: Detection of this mutation through liquid biopsy offers a less invasive alternative to conventional tissue biopsies, with potential utility in guiding treatment adjustments and monitoring therapeutic response.

Outlook: The use of liquid biopsy for the detection of BRAF V600E is expected to widespread in clinical practice, leading to the optimization of disease monitoring and personalized treatments for cancer patients.

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