Long-Term Tumor Control After Carbon Ion Radiation Therapy Boost in Locally Advanced Cervical Clear Cell Adenocarcinoma.

Clear cell adenocarcinoma of the uterine cervix is a rare and aggressive subtype of cervical cancer, typically resistant to conventional radiation therapy and lacking dedicated treatment guidelines. We present the case of a young patient with an ataxia telangiectasia mutation and locally advanced disease, who was unfit for brachytherapy following standard chemoradiotherapy and subsequently received a carbon ion radiation therapy boost. This mixed-beam strategy was well tolerated and led to durable local control along with a nodal response, which is suggestive of a possible abscopal effect. These findings underscore the potential of carbon ion radiation therapy in overcoming radioresistance and suggest a contributory role of genetic background in mediating systemic immune effects.