类风湿关节炎的发病机制:回顾2025年。

IF 3.4 4区 医学 Q2 RHEUMATOLOGY
Giulia Noto, Francesca Salvetti, Adriana Demaj, Piera Altieri, Erica Chericoni, Elisa Ferrigno, Alessia Alunno, Ilaria Puxeddu
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引用次数: 0

摘要

类风湿性关节炎(RA)是一种慢性炎症性自身免疫性疾病,以关节破坏和关节外表现为特征。先天免疫系统和适应性免疫系统之间的密切相互作用导致该疾病的临床特征的发展,其特征是炎症和结构变化。RA基础研究和临床研究的进展,提高了对RA发病机制的认识。从RA的基础和临床研究中获得的数据积极有助于确定新的潜在靶点,为设计个性化的疾病治疗方法提供新的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pathogenesis of rheumatoid arthritis: one year in review 2025.

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterised by joint destruction and extra-articular manifestations. A close interaction between both innate and adaptive immune systems leads to the development of the clinical features of the disease, characterised by inflammation and structural changes. Progress in the basic and clinical research in the field of RA has improved the current knowledge on the mechanisms underlying its pathogenesis. The data obtained from basic and clinical studies in RA has actively contributed to identifying new potential targets for novel therapeutic approaches to design personalised therapy of the disease.

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来源期刊
CiteScore
6.10
自引率
18.90%
发文量
377
审稿时长
3-6 weeks
期刊介绍: Clinical and Experimental Rheumatology is a bi-monthly international peer-reviewed journal which has been covering all clinical, experimental and translational aspects of musculoskeletal, arthritic and connective tissue diseases since 1983.
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