阿曲南-那库巴坦与头孢吡肟-那库巴坦抗嗜麦芽窄养单胞菌临床分离株体外疗效评价。

IF 4.5 2区医学 Q2 MICROBIOLOGY

Antimicrobial Agents and Chemotherapy Pub Date : 2025-09-22 DOI:10.1128/aac.00755-25

Wataru Aoki, Yoshifumi Uwamino, Hiroaki Kubota, Yuka Kamoshita, Rika Inose, Mika Nagata, Ho Namkoong, Hiromichi Matsushita

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引用次数: 0

摘要

研究了氨曲南-纳库巴坦（ATM-NAC）和头孢吡肟-纳库巴坦（FEP-NAC）对53株嗜麦芽窄养单胞菌的体外抑菌活性。通过肉汤微量稀释测定最低抑菌浓度（mic）。尽管头孢吡肟是L1 β-内酰胺酶的底物，但ATM-NAC显示出更显著的MIC降低，FEP-NAC也显著降低MIC。这些发现表明β-内酰胺- nac联合治疗是一种有希望的替代方案，需要进一步的体内研究来证实临床适用性。

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Evaluation of in vitro efficacy of aztreonam-nacubactam and cefepime-nacubactam against clinical isolates of Stenotrophomonas maltophilia.

We evaluated the in vitro activity of aztreonam-nacubactam (ATM-NAC) and cefepime-nacubactam (FEP-NAC) against 53 clinical isolates of Stenotrophomonas maltophilia from blood cultures. Minimum inhibitory concentrations (MICs) were determined via broth microdilution. While ATM-NAC showed more significant MIC reduction, FEP-NAC also remarkably decreased MICs, despite cefepime being a substrate for L1 β-lactamase. These findings suggest the potential of β-lactam-NAC combinations as promising alternatives, warranting further in vivo studies to confirm clinical applicability.

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来源期刊

Antimicrobial Agents and Chemotherapy 医学-微生物学

CiteScore

10.00

自引率

8.20%

发文量

762

审稿时长

3 months

期刊介绍： Antimicrobial Agents and Chemotherapy (AAC) features interdisciplinary studies that build our understanding of the underlying mechanisms and therapeutic applications of antimicrobial and antiparasitic agents and chemotherapy.