舒巴坦-杜氯巴坦在鲍曼不动杆菌脑室炎患者中的药代动力学：附2例报告。

IF 4.5 2区医学 Q2 MICROBIOLOGY

Antimicrobial Agents and Chemotherapy Pub Date : 2025-09-22 DOI:10.1128/aac.00674-25

Nazanin Pouya, Natalie A Finch, Alejandro Granillo, Adarsh Bhimraj, Vincent H Tam, William R Miller

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引用次数: 0

摘要

两位因鲍曼不动杆菌引起的脑室炎的成年患者接受静脉注射舒巴坦-杜氯巴坦作为联合治疗方案的一部分。舒巴坦（0.47-0.64）和杜氯巴坦（0.27-0.3）对中枢神经系统的渗透程度(通过稳态时脑脊液（CSF) /血清曲线下面积（AUC）比）进行了估计。鉴于大多数脑脊液浓度恒定，稳定状态下的单一脑脊液水平可能提供更方便和临床适用的监测治疗方法。

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Pharmacokinetics of sulbactam-durlobactam in patients with Acinetobacter baumannii ventriculitis: a report of two cases.

Two adult patients with ventriculitis due to Acinetobacter baumannii were treated with intravenous sulbactam-durlobactam as a part of a combination regimen. Penetration into the central nervous system was estimated (by cerebrospinal fluid [CSF]/serum area under the curve [AUC] ratios at steady state) for sulbactam (0.47-0.64) and durlobactam (0.27-0.3), respectively. In view of mostly constant CSF concentrations, single CSF levels at steady state may offer a more convenient and clinically applicable approach for monitoring therapy.

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来源期刊

Antimicrobial Agents and Chemotherapy 医学-微生物学

CiteScore

10.00

自引率

8.20%

发文量

762

审稿时长

3 months

期刊介绍： Antimicrobial Agents and Chemotherapy (AAC) features interdisciplinary studies that build our understanding of the underlying mechanisms and therapeutic applications of antimicrobial and antiparasitic agents and chemotherapy.