微胶囊对老年人群中益生菌对大脑结构和功能的不同影响——一项随机安慰剂对照试验

IF 7.6 2区 医学 Q1 IMMUNOLOGY
Julia Rode , Ashley N. Hutchinson , Myrto S. Chatzopoulou , Sinéad B. Bleiel , Rediet Fikru Gebresenbet , Linda Andersson , Jonas Persson , Romain Daillère , Benoît Beitz , Bouthaina Ben Abdallah , Lina Tingö , Cecilia Bergh , Robert J. Brummer
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引用次数: 0

摘要

越来越多的证据表明,益生菌对肠脑轴的调节影响健康的衰老。这项双盲、随机、安慰剂对照研究比较了微胶囊化和非胶囊化鼠李糖乳杆菌HN001对87名社区老年人(60-80 岁)的影响。在两个益生菌组之间,静息状态功能连通性在涉及视觉加工和感知的区域有显著差异(p
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Micro-encapsulation differentially impacts probiotic effects on brain structure and function in an elderly population – A randomised placebo-controlled trial
Increasing evidence suggests that modulations of the gut-brain axis with probiotics impact healthy ageing. This double-blinded, randomised, placebo-controlled study compared effects of micro-encapsulated and non-encapsulated Lacticaseibacillus rhamnosus HN001 in 87 community-dwelling elderly (60–80 years). Resting state functional connectivity differed significantly in regions involved in visual processing and perception between the two probiotic groups (p < 0.0001). Brain morphometry was not altered. Significant time*group effects (p < 0.05) were observed for processing speed, non-significant effects were observed for short-term memory and anxiety symptoms, while other cognitive domains, depression, perceived stress, and sleep quality were unaffected. Distribution of available and stored peripheral serotonin was significantly affected (p < 0.05), while levels of γ-aminobutyric acid and glutamate in striatum and circulating brain-derived neurotrophic factor did not show significant time*group effects. Micro-encapsulated probiotics target the gut differently, which impacts the effects on brain health assessed by (functional) magnetic resonance imaging in older adults.
The trial is registered at ClinicalTrials.gov under ID: NCT05801042.
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来源期刊
CiteScore
29.60
自引率
2.00%
发文量
290
审稿时长
28 days
期刊介绍: Established in 1987, Brain, Behavior, and Immunity proudly serves as the official journal of the Psychoneuroimmunology Research Society (PNIRS). This pioneering journal is dedicated to publishing peer-reviewed basic, experimental, and clinical studies that explore the intricate interactions among behavioral, neural, endocrine, and immune systems in both humans and animals. As an international and interdisciplinary platform, Brain, Behavior, and Immunity focuses on original research spanning neuroscience, immunology, integrative physiology, behavioral biology, psychiatry, psychology, and clinical medicine. The journal is inclusive of research conducted at various levels, including molecular, cellular, social, and whole organism perspectives. With a commitment to efficiency, the journal facilitates online submission and review, ensuring timely publication of experimental results. Manuscripts typically undergo peer review and are returned to authors within 30 days of submission. It's worth noting that Brain, Behavior, and Immunity, published eight times a year, does not impose submission fees or page charges, fostering an open and accessible platform for scientific discourse.
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