封面：离子对和氢键在皮摩尔灵敏度比色法检测胰岛素原纤维中的作用（ChemPhotoChem 9/2025）

IF 3 4区化学 Q3 CHEMISTRY, PHYSICAL

ChemPhotoChem Pub Date : 2025-09-22 DOI:10.1002/cptc.70039

Ayentika Sen, Aruna K. Mora, Soumitra Kundu, Sukhendu Nath

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引用次数: 0

摘要

利用吡啶1作为离子对存在于水中，实现了淀粉样蛋白纤维的超灵敏检测（LOD = 2pm）。淀粉样蛋白诱导的离子对解离和纤维凹槽内缺乏氢键的独特特征已被确定为淀粉样蛋白原纤维的超灵敏比色检测发挥关键作用。更多信息可以在Aruna K. Mora， Sukhendu Nath及其同事的研究文章中找到（DOI: 10.1002/cptc.202400329）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Front Cover: Role of Ion-Pair and H-Bonding in Colorimetric Detection of Insulin Fibrils with Picomolar Sensitivity (ChemPhotoChem 9/2025)

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Front Cover: Role of Ion-Pair and H-Bonding in Colorimetric Detection of Insulin Fibrils with Picomolar Sensitivity (ChemPhotoChem 9/2025)

Ultrasensitive detection (LOD = 2 pM) of amyloid fibril is achieved using Pyridine 1 which exists as an ion-pair in water. A unique feature of amyloid-induced dissociation of this ion-pair and lack of hydrogen bonding inside the fibrillar grooves have been established to play a pivotal role for ultrasensitive colorimetric detection of amyloid fibrils. More information can be found in the Research Article by Aruna K. Mora, Sukhendu Nath, and co-workers (DOI: 10.1002/cptc.202400329).

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来源期刊

ChemPhotoChem Chemistry-Physical and Theoretical Chemistry

CiteScore

5.80

自引率

5.40%

发文量

165

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